Evidence map›Paper›PMID 36093702›Full record

ArticleJournal of Alzheimer's disease : JAD2022

Fatty Acid-Binding Protein 3 Is a Marker of Neurodegeneration and White Matter Hyperintensity Burden in Mexican American Older Adults.

Alexandra L Clark, Andreana P Haley, Audrey Duarte, Sid O'Bryant, Health and Aging Brain Study – Health Disparities (HABS-HD) Study Team

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alexandra L ClarkDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.
Andreana P HaleyDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.
Audrey DuarteDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.
Sid O'BryantInstitute for Translational Research, University of North Texas Health Science Center, Fort Worth, TX, USA.
Health and Aging Brain Study – Health Disparities (HABS-HD) Study Team
The University of Texas at Austin · USUniversity of North Texas · US

Funding

Health and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
RESEARCH TRAINING IN COGNITIVE AGINGT32AG000175 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI DUARTE, AUDREY · 1988 to 2020
$5.6M
NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058533NIA NIH HHS T32 AG000175
6 · The paper itself

Abstract

We examined ethnoracial differences in fatty acid binding protein (FABP)-a family of intracellular lipid carriers-and clarified FABP3 associations with gray and white matter. Relative to Mexican Americans (MAs), FABP3 was higher in Non-Hispanic Whites (NHWS, p < 0.001). Regressions revealed, independent of traditional AD markers, FABP3 was associated with neurodegeneration (B = -0.08, p = 0.003) and WMH burden (B = 0.18, p = 0.03) in MAs, but not in NHWs (ps > 0.18). Findings suggest FABP3 is related to neural health within MAs and highlight its potential as a prognostic marker of brain health in ethnoracially diverse older adults.

Indexed as

Neurodegenerative DiseasesWhite MatterAgedBiomarkersBrainFatty Acid Binding Protein 3HumansMagnetic Resonance ImagingMexican AmericansWhiteBiomarkersFABP3 protein, humanFatty Acid Binding Protein 3Alzheimer’s diseaseFABP3Hispanic/Latinolipid dyshomeostasismild cognitive impairment

Identifiers

PMID36093702
PMCPMC11234903
OpenAlexW4294770404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.