Evidence map›Paper›PMID 36093582›Full record

ReviewInternational journal of cancer2023

Assessing the risk of cervical neoplasia in the post-HPV vaccination era.

Matti Lehtinen, Ville N Pimenoff, Belinda Nedjai, Karolina Louvanto, Lisanne Verhoef, Daniëlle A M Heideman, Mariam El-Zein, Martin Widschwendter, Joakim Dillner

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in International journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02149030 (Effectiveness of Cervical Screening in HPV Vaccinated Women - a Randomized Trial), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02149030 naactive not recruitingnot on this map

Effectiveness of Cervical Screening in HPV Vaccinated Women - a Randomized Trial

TypeinterventionalSponsorTampere UniversityRan2014 to 2025Enrolled6,958ConditionsCervical Intraepithelial Neoplasia Grade 2/3ArmsCytological screening in A1 and A3
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. Cytologic DNA methylation for managing minimally abnormal cervical cancer screening results.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 6 countries.

Matti LehtinenMedical Faculty, Tampere University, Tampere, Finland.ORCID 0000-0002-9481-0535
Ville N PimenoffDepartment of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-0813-7031
Belinda NedjaiWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Karolina LouvantoMedical Faculty, Tampere University, Tampere, Finland.
Lisanne VerhoefDepartment of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-9877-0297
Daniëlle A M HeidemanDepartment of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Mariam El-ZeinDivision of Cancer Epidemiology, McGill University, Montreal, Canada.
Martin WidschwendterEuropean Translational Oncology Prevention and Screening (EUTOPS) Institute, Universität Innsbruck, Hall in Tirol, Austria.
Joakim DillnerDepartment of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0001-8588-6506
Dutch Cancer Society · NLKarolinska Institutet · SETampere University · FIKarolinska University Hospital · SEMcGill University Health Centre · CAQueen Mary University of London · GB

Funding

Cancer Research UK 21070Cancer Research UK 27046
6 · The paper itself

Abstract

This review is based on the recent EUROGIN scientific session: "Assessing risk of cervical cancer in the post-vaccination era," which addressed the demands of cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesion (SIL) triage now that the prevalence of vaccine-targeted oncogenic high-risk (hr) human papillomaviruses (HPVs) is decreasing. Change in the prevalence distribution of oncogenic HPV types that follows national HPV vaccination programs is setting the stage for loss of positive predictive value of conventional but possibly also new triage modalities. Understanding the contribution of the latter, most notably hypermethylation of cellular and viral genes in a new setting where most oncogenic HPV types are no longer present, requires studies on their performance in vaccinated women with CIN/SIL that are associated with nonvaccine HPV types. Lessons learned from this research may highlight the potential of cervical cells for risk prediction of all women's cancers.

Indexed as

Papillomavirus InfectionsPapillomavirus VaccinesUterine Cervical DysplasiaUterine Cervical NeoplasmsFemaleHumansPapillomaviridaePredictive Value of TestsVaccinationPapillomavirus Vaccinescervical cancerepigeneticsgynecological cancershuman papillomavirusmethylation

Identifiers

PMID36093582
PMCPMC10091767
OpenAlexW4295234014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.