Evidence map›Paper›PMID 36093575›Full record

SynthesisInternational journal of cancer2023

Morning chronotype and digestive tract cancers: Mendelian randomization study.

Shuai Yuan, Amy M Mason, Olga E Titova, Mathew Vithayathil, Siddhartha Kar, Jie Chen, Xue Li, Stephen Burgess, Susanna C Larsson

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Sleep duration, selected circulating biomarkers, and colorectal cancer risk.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026
    Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Impact of sleep on gastrointestinal cancer.World journal of clinical oncology · 2024
    Article
  19. Article
  20. Sleep and Risk of Pancreatic Cancer in the UK Biobank.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Shuai YuanUnit of Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-5055-5627
Amy M MasonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Olga E TitovaBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mathew VithayathilMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Siddhartha KarMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Jie ChenCentre for Global Health, Zhejiang University School of Medicine, Hangzhou, China.
Xue LiDepartment of Big Data in Health Science School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Stephen BurgessMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Susanna C LarssonUnit of Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-0118-0341
University of Cambridge · GBUppsala University · SEKarolinska Institutet · SESecond Affiliated Hospital of Zhejiang University · CNUniversity of Bristol · GBZhejiang University · CN

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Department of Health BRC-1215-20014Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00002/7Wellcome Trust 204623
6 · The paper itself

Abstract

Morning chronotype has been associated with a reduced risk of prostate and breast cancer. However, few studies have examined whether chronotype is associated with digestive tract cancer risk. We conducted a Mendelian randomization (MR) study to assess the associations of chronotype with major digestive tract cancers. A total of 317 independent genetic variants associated with chronotype at the genome-wide significance level (P < 5 × 10

Indexed as

Colorectal NeoplasmsGastrointestinal NeoplasmsChronotypeGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk Factorschronotypecolorectal cancerdigestive system cancergastric cancerMendelian randomization

Identifiers

PMID36093575
PMCPMC7613990
OpenAlexW4295234387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.