Evidence map›Paper›PMID 36093351›Full record

ArticlemedRxiv : the preprint server for health sciences2022

Deep immune profiling uncovers novel associations with clinical phenotypes of Multisystem Inflammatory Syndrome in Children (MIS-C).

Christopher Redmond, Moses M Kitakule, Aran Son, McKella Sylvester, Keith Sacco, Ottavia Delmonte, Francesco Licciardi, Riccardo Castagnoli, Cecilia Poli, Yasmin Espinoza and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 4 countries.

Christopher RedmondVasculitis Translational Research Section, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health.
Moses M KitakuleColumbia University Vagelos College of Physicians and Surgeons.
Aran SonLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
McKella SylvesterVasculitis Translational Research Section, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health.
Keith SaccoPhoenix Children's Hospital.
Ottavia DelmonteImmune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Francesco LicciardiImmune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Riccardo CastagnoliImmune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Cecilia PoliFaculty of Medicine, Clinica Alemana Universidad del Desarrollo.
Yasmin EspinozaDivision of Immunology and Rheumatology, Hospital Roberto del Rio.
Camila AstudilloDivision of Immunology and Rheumatology, Hospital Roberto del Rio.
Sarah E WeberMolecular Development of the Immune System Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Gina A Montealegre SanchezDivision of Clinical Medicine, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Karyl BarronOffice of the Scientific Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Mary MaglioccoImmune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Kerry DobbsImmune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Yu ZhangImmune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Helen MatthewsImmune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Cihan OguzResearch Technologies Branch, Collaborative Bioinformatics Resource, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Helen C SuHuman Immunological Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Luigi D NotarangeloImmune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Pamela A Frischmeyer-GuerrerioLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Daniella M SchwartzLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
National Institutes of Health · USHospital Roberto del Rio · CLColumbia College · CAUniversidad del Desarrollo · CLUniversity of Arizona · US

Funding

Vasculitis and Translational MedicineZIAAR041204 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GRAYSON, PETER · 2015 to 2025
$15.4M
T cell responses in MIS-C related to SARS-CoV2ZIAAI001274 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SCHWARTZ, DANIELLA · 2020 to 2022
$71k
Intramural NIH HHS ZIA AI001274Intramural NIH HHS ZIA AR041204
6 · The paper itself

Abstract

Multisystem Inflammatory Syndrome in Children (MIS-C) is a systemic inflammatory condition that follows SARS-CoV2 infection or exposure in children. Clinical presentations are highly variable and include fever, gastrointestinal (GI) disease, shock, and Kawasaki Disease-like illness (MIS-C/KD). Compared to patients with acute COVID, patients with MIS-C have a distinct immune signature and expansion of

Identifiers

PMID36093351
PMCPMC9460975
OpenAlexW4294335516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.