Evidence map›Paper›PMID 36093327›Full record

ArticleBioactive materials2023

Cobalt protoporphyrin-induced nano-self-assembly for CT imaging, magnetic-guidance, and antioxidative protection of stem cells in pulmonary fibrosis treatment.

Yimeng Shu, Ming Ma, Xiaoxia Pan, Muhammad Shafiq, Huizhu Yu, Hangrong Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yimeng ShuState Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
Ming MaState Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
Xiaoxia PanState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, PR China.
Muhammad ShafiqDepartment of Biotechnology, Faculty of Science and Technology, University of Central Punjab (UCP), Lahore, 54000, Pakistan.
Huizhu YuState Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
Hangrong ChenState Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
Chinese Academy of Sciences · CNFudan University · CNUniversity of Central Punjab · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) transplantation is a promising approach for pulmonary fibrosis (PF), however it is impeded by several persistent challenges, including the lack of long-term tracking, low retention, and poor survival of MSCs, as well as the low labeling efficiency of nanoprobes. Herein, a cobalt protoporphyrin IX (CoPP) aggregation-induced strategy is applied to develop a multifunctional nano-self-assembly (ASCP) by combining gold nanoparticle (AuNPs), superparamagnetic iron oxide nanoparticles (SPIONs), and CoPP through a facile solvent evaporation-driven approach. Since no additional carrier materials are employed during the synthesis, high loading efficiency of active ingredients and excellent biocompatibility are achieved. Additionally, facile modification of the ASCPs with bicyclo[6.1.0]nonyne (BCN) groups (named as ASCP-BCN) enables them to effectively label MSCs through bioorthogonal chemistry. The obtained ASCP-BCN could not only help to track MSCs with AuNP-based computed tomography (CT) imaging, but also achieve an SPIONs-assisted magnetic field based improvement in the MSCs retention in lungs as well as promoted the survival of MSCs

Indexed as

Cell labelingPulmonary fibrosisSelf-assemblyStem cell therapyTheranostic

Identifiers

PMID36093327
PMCPMC9411585
OpenAlexW4292096805

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.