Evidence map›Paper›PMID 36093113›Full record

ArticleFrontiers in endocrinology2022

Acupuncture ameliorates breast cancer-related fatigue by regulating the gut microbiota-gut-brain axis.

Zhuan Lv, Ruidong Liu, Kaiqi Su, Yiming Gu, Lu Fang, Yongfu Fan, Jing Gao, Xiaodi Ruan, Xiaodong Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 8 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 8 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  9. Modulation of the gut microbiota by traditional Chinese medicine to attenuate chemotherapy-induced toxicity in gastric cancer: a review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  10. Recent advances in understanding chemotherapy-induced fatigue in BC patients residing in high-altitude regions: a review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  12. Post-treatment adaptation experiences of women breast cancer survivors: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhuan LvDepartment of Rehabilitation Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Ruidong LiuDepartment of Breast surgery, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Kaiqi SuDepartment of Rehabilitation Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Yiming GuDepartment of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Lu FangDepartment of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Yongfu FanDepartment of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Jing GaoDepartment of Rehabilitation Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Xiaodi RuanDepartment of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Xiaodong FengDepartment of Rehabilitation Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
First Affiliated Hospital of Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-related fatigue (CRF) is the most common side effect of chemotherapy for breast cancer (BC). Acupuncture treatment has an anti-fatigue effect and can regulate gut microbiota disturbance in fatigue patients. Related studies have shown that the gut microbiota-gut-brain axis is closely related to the occurrence of CRF. In this study, we first investigated the alterations of acupuncture on fatigue-like behavior, gut microbiota, gut inflammation and neuroinflammation response, gut barriers, HPA axis, and serum metabolomics in CRF mice after BC chemotherapy. Then, the correlation analysis of gut microbiota and other indicators was discussed. Our results showed that acupuncture treatment could exert an anti-fatigue effect and ameliorate the gut barrier, gut inflammation, neuroinflammation, and dysfunction of the HPA axis in CRF mice after chemotherapy for BC. 16S rRNA sequencing showed that acupuncture treatment could enhance the abundance of

Indexed as

Acupuncture TherapyGastrointestinal MicrobiomeNeoplasmsAnimalsBrain-Gut AxisHypothalamo-Hypophyseal SystemInflammationMicePituitary-Adrenal SystemRNA, Ribosomal, 16SRNA, Ribosomal, 16Sacupuncture treatmentbreast cancercancer-related fatigue (CRF)chemotherapygut microbiota-gut-brain axis

Identifiers

PMID36093113
PMCPMC9449876
OpenAlexW4293113423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.