ArticleFrontiers in endocrinology2022
Lifetime risk and health-care burden of diabetic ketoacidosis: A population-based study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic literature review on the burden of diabetic ketoacidosis in type 2 diabetes mellitus.Diabetes, obesity & metabolism · 2025Pooled it
- Incidence and predictors of diabetic ketoacidosis among adults with type 1 diabetes in Northwest, Ethiopia, 2023: a retrospective cohort study.BMC public health · 2026Article
- Article
- Acute kidney injury and length of ICU stay in diabetic ketoacidosis: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Mapping the storm: a scoping review of diabetic emergencies in Africa.Frontiers in clinical diabetes and healthcare · 2026Review
- Association between triglyceride-glucose index upon admission and the subsequent occurrence of acute kidney injury in adult patients with diabetic ketoacidosis: a single-center retrospective cohort study.Annals of medicine · 2025Article
- Association of diabetic ketoacidosis and retinopathy in patients with type 2 diabetes: a nationwide cohort study.Scientific reports · 2025Article
- The health economics of insulin therapy: How do we address the rising demands, costs, inequalities and barriers to achieving optimal outcomes.Diabetes, obesity & metabolism · 2025Article
- Alcohol-Related Hospitalizations Among Adolescents and Young Adults with Type 1 Diabetes in Spain, 2016-2023.Journal of clinical medicine · 2025Article
- Diabetic ketoacidosis treatment outcomes and associated factors among adult diabetic patients in Ethiopia: A systematic review and meta-analysis.Metabolism open · 2025Article
- Recovery time of diabetic ketoacidosis in Africa: Systematic review and meta-analysis.Metabolism open · 2025Article
- Lymphocyte-C-reactive protein ratio upon admission to predict disease progression and ICU admission in adult patients with diabetic ketoacidosis.Scientific reports · 2025Article
- Perception and Awareness of Diabetes Mellites and Diabetes Ketoacidosis among the General Population in Sudair Area, Saudi Arabia.Journal of pharmacy & bioallied sciences · 2024Article
- Awareness and knowledge of diabetic ketoacidosis in people with type 1 diabetes: a cross-sectional, multicenter survey.BMJ open diabetes research & care · 2023Article
- Differential evolution of diabetic ketoacidosis in adults with pre-existent versus newly diagnosed type 1 and type 2 diabetes mellitus.BMC endocrine disorders · 2023Article
- Unmasking a Hidden Burden: Chemotherapy-Induced and Exacerbated Diabetes in Paediatric Cancer: A Report of Two Cases.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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4 authors.
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Abstract
Objective: Diabetic ketoacidosis (DKA) is a life-threatening complication of both type 1 and type 2 diabetes. We aimed to assess population-based rates, trends and outcomes of patients with DKA. Design and methods: This is a nationwide cohort study using hospital discharge claims data from 2010 to 2018 in Switzerland. Incidence rates and in-hospital outcomes of DKA were analyzed throughout lifetime for children (0-9 years), adolescents (10-19 years), and adults (20-29, 30-59, and 60-90 years). Analyses were stratified for type of diabetes mellitus and sex. Results: In total, 5,544 hospitalizations with DKA were identified, of whom 3,847 were seen in patients with type 1 diabetes and 1,697 in type 2 diabetes. Incidence rates of DKA among patients with type 1 diabetes were highest during adolescence with 17.67 (girls) and 13.87 (boys) events per 100,000 person-years (incidence rate difference [IRD]: -3.80 [95% CI, -5.59 to -2.02]) and decreased with age in both sexes thereafter. Incidence rates of DKA in patients with type 2 diabetes were low up to an age of 40 years and rose to 5.26 (females) and 6.82 (males) per 100,000 person-years in adults aged 60-90 years. Diabetic ketoacidosis was associated with relevant health-care burden independent of age, sex, or type of diabetes. The population-based incidence rate of DKA increased over time from 7.22 per 100,000 person-years in 2010 to 9.49 per 100,000 person-years in 2018. Conclusions: In type 1 diabetes highest incidence rates of DKA hospitalizations were observed among adolescent females. In comparison, in patients with type 2 diabetes the risk for DKA steadily increased with age with higher rates in adult males. Over the 9 year study period, incidence rates of DKA were increasing irrespective of type of diabetes. DKA was associated with a high burden of disease reflected by high rates of intensive care unit admission, prolonged hospital stay and high mortality rates, especially in elderly.
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