Evidence map›Paper›PMID 36093055›Full record

ArticleiScience2022

Yin and yang of cannabinoid CB1 receptor: CB1 deletion in immune cells causes exacerbation while deletion in non-immune cells attenuates obesity.

Kathryn Miranda, William Becker, Philip B Busbee, Nicholas Dopkins, Osama A Abdulla, Yin Zhong, Jiajia Zhang, Mitzi Nagarkatti, Prakash S Nagarkatti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. CBInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kathryn MirandaDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
William BeckerDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Philip B BusbeeDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Nicholas DopkinsDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Osama A AbdullaDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Yin ZhongDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Jiajia ZhangEpidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Mitzi NagarkattiDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Prakash S NagarkattiDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
University of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested. The current study investigated the role of CB1 in immune vs non-immune cells during DIO by generating radiation-induced bone marrow chimeric mice that expressed functional CB1 in all cells except the immune cells or expressed CB1 only in immune cells. CB1

Indexed as

HematologyHuman metabolismImmunology

Identifiers

PMID36093055
PMCPMC9460165
OpenAlexW4292840681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.