Evidence map›Paper›PMID 36093049›Full record

ArticleiScience2022

Uncovering lipopolysaccharide regulation in bacteria via the critical lipid binding tunnel of YciS/YciM.

Lina Yan, Haohao Dong, Huanyu Li, Xingyu Liu, Zixin Deng, Changjiang Dong, Zhengyu Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Signaling through theJournal of bacteriology · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lina YanSchool of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Haohao DongState Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Huanyu LiStructural Genomics Consortium, University of Oxford, Oxford.
Xingyu LiuCollege of chemistry and molecular sciences, Wuhan University, Wuhan, Hubei, China.
Zixin DengSchool of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Changjiang DongSchool of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Zhengyu ZhangSchool of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Wuhan University · CNSichuan University · CNUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative bacteria contain an asymmetric outer membrane, in which the outer leaflet is composed of lipopolysaccharide (LPS). LPS, a drug target of polymyxin, plays an essential role in drug resistance, biofilm formation, and pathogenesis. An important inner membrane protein, YciM, may be responsible for the regulation of LPS biosynthesis and transport. Here, we report the crystal structure of YciM from

Indexed as

BacteriologyBiological sciencesMicrobiologyMolecular biologyStructural biology

Identifiers

PMID36093049
PMCPMC9460159
OpenAlexW4292805317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.