ReviewiScience2022
Recent developments in one-pot stepwise synthesis (OPSS) of small molecules.
Review in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Synthesis of Spiro-Bridged 3,4-Dihydrocoumarins Through an Organocatalytic Cascade Sequence Diels-Alder/Nucleophilic Ring Closing.Molecules (Basel, Switzerland) · 2026Article
- One-Pot Nucleophilic Organocatalytic Enantioselective [8 + 2] Cycloadditions of Photogenerated Ketenes with Triflate Tropolones.Organic letters · 2026Article
- Solvent-Controlled Chemoselectivity in Brønsted Acidic Deep Eutectic Mixtures: A Metal-Free One-Pot Cascade Meyer-Schuster/C-P Bond Formation.ChemSusChem · 2026Article
- Synthesis and anti-antileishmanial profile of novel thiazolidine-4-one derivatives and molecular docking and molecular dynamics simulations studies.Scientific reports · 2026Article
- Streamlined One-Pot Synthesis of Fused Pyrroles: A Three-Component Approach.ChemistryOpen · 2026Article
- Ball-mill-assisted mechanochemical approaches for heterocyclic compound synthesis (2015-2024).Molecular diversity · 2026Review
- Engineered strains as living factories: efficient biosynthesis and modification of natural products via synthetic biology and one-pot chemical tandem reactions.Frontiers in microbiology · 2026Review
- A three-step, one-pot strategy to unsymmetrical 1,1-diarylalkenes.BMC research notes · 2025Article
- AIE-active fluorescent probes as 'turn-off' sensors for the selective detection of CrRSC advances · 2025Article
- Metal-free molecular editing of indole via tandem reaction: Access to 2-aryl-3-aryldiazenylindole for theranostic applications.iScience · 2025Article
- Synthesis of thiosemicarbazone Schiff base derivatives as anti-leishmanial agents and molecular dynamics simulations insights.Scientific reports · 2025Article
- Advances in Mechanochemical Methods for One-Pot Multistep Organic Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Radical-Mediated Trifunctionalization Reactions.Molecules (Basel, Switzerland) · 2024Review
- One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline.Beilstein journal of organic chemistry · 2024Article
- Decarboxylative 1,3-dipolar cycloaddition of amino acids for the synthesis of heterocyclic compounds.Beilstein journal of organic chemistry · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One-pot synthesis is an active topic in organic chemistry due to its intrinsic advantages of simple operation, high mass efficiency, low cost, and less amount of waste disposal. Among three kinds of one-pot syntheses, 1) cascade reactions, 2) multicomponent reactions (MCRs), and 3) one-pot stepwise synthesis (OPSS), OPSS could be more flexible and practical since it is carried out stepwisely and have variable reaction conditions for different steps. This perspective article uses selected examples to highlight the recent development in OPSS involving cyclization, cycloaddition, rearrangement, and catalytic reactions for the synthesis of heterocyclic scaffolds, asymmetric molecules, natural products, and bioactive compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.