Evidence map›Paper›PMID 36093029›Full record

ArticleChemical science2022

Flexible organic frameworks sequester neuromuscular blocking agents

Yan Wu, Yue-Yang Liu, Hong-Kun Liu, Shang-Bo Yu, Furong Lin, Wei Zhou, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li, Da Ma

Open access · diamondAbstract read

In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.9field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

Nanotherapeutics for Alleviating Anesthesia-Associated Complications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yan WuDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0001-5474-5663

Yue-Yang LiuDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0001-7199-1233

Hong-Kun LiuDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.

Shang-Bo YuKey Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China.ORCID https://orcid.org/0000-0001-7186-367X

Furong LinKey Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China.ORCID https://orcid.org/0000-0001-5732-6253

Wei ZhouDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0001-7467-3628

Hui WangDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.

Dan-Wei ZhangDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0003-1244-1850

Zhan-Ting LiDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University Shanghai 200438 China zhouw@fudan.edu.cn zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0003-3954-0015

Da MaSchool of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University 1139 Shifu Avenue, Jiaojiang Zhejiang 318000 China dama@fudan.edu.cn.ORCID https://orcid.org/0000-0002-5300-7500

Fudan University · CNChinese Academy of Sciences · CNTaizhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Supramolecular sequestration and reversal of neuromuscular block (NMB) have great clinical applications. Water-soluble flexible organic frameworks (FOFs) cross-linked by disulfide bonds are designed and prepared. Different linker lengths are introduced to FOFs to give them varied pore sizes. FOFs are anionic nanoscale polymers and capable of encapsulating cationic neuromuscular blocking agents (NMBAs), including rocuronium (Roc), vecuronium (Vec), pancuronium (Panc) and cisatracurium (Cis). A host-guest study confirms that FOFs bind NMBAs in water. The multivalency interaction between FOFs and NMBAs is able to sequester NMBAs, and prevent them from escaping. These FOFs are non-toxic and biocompatible. Animal studies show that FOFs are effective for the reversal of NMB induced by Roc, Vec and Cis, which shorten the time to a train-of-four ratio of 0.9 by 2.6, 3.8 and 5.7-fold compared to a placebo, respectively.

Identifiers

PMID36093029

DOI10.1039/d2sc02456j

PMCPMC9384803

OpenAlexW4286356576

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.