ArticleChemical science2022
Palladium-catalyzed difluoroalkylative carbonylation of styrenes toward difluoropentanedioates.
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Pd-Catalyzed Hydroalkoxycarbonylation and Hydroxycarbonylation: DFT Mapping of Catalyst-Substrate Landscape for Product Selectivity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Biomimetic sulfur-catalyzed carbonyl transfer enables the carbonylative difunctionalization of unactivated alkenes.Chemical science · 2026Article
- Recent Advances in Single-Electron-Transfer-Mediated Carbonylation.Chemical reviews · 2026Review
- Palladium-Catalyzed Carbonylative Fluoroalkylation of 1,3-Enynes to Access Allenyl Primary Amides.Organic letters · 2025Article
- Palladium-Catalyzed Intermolecular Tandem Difunctional Carbonylation of 1,3-Enynes: Synthesis of Fluoroalkylated Butenolides.Organic letters · 2025Article
- Hydrogen Bond Promoted Carbonylative Lactonization of Alkenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Single-Electron-Transfer-Mediated Carbonylation Reactions.Accounts of chemical research · 2025Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The introduction of fluorine atoms into organic molecules is an attractive but challenging topic. In this work, an interesting palladium-catalyzed difluoroalkylative carbonylation of aryl olefins has been developed. A wide range of aryl olefins were transformed into the corresponding difluoropentanedioate compounds with good functional-group tolerance and excellent regioselectivity. Inexpensive ethyl bromodifluoroacetate acts both as a difluoroalkyl precursor and a nucleophile here. Additionally, a scale-up reaction was also performed successfully, and further transformations of the obtained product were shown as well.
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Registered trials
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