Evidence map›Paper›PMID 36092940›Full record

ArticleFrontiers in genetics2022

The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media.

Arwa Kurabi, Dong Gu Hur, Kwang Pak, Madeline Gibson, Nicholas J G Webster, Andrew Baird, Brian P Eliceiri, Allen F Ryan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Arwa KurabiDepartment of Otolaryngology, University of California, San Diego, La Jolla, CA, United States.
Dong Gu HurDepartment of Otolaryngology, University of California, San Diego, La Jolla, CA, United States.
Kwang PakDepartment of Otolaryngology, University of California, San Diego, La Jolla, CA, United States.
Madeline GibsonDepartment of Otolaryngology, University of California, San Diego, La Jolla, CA, United States.
Nicholas J G WebsterDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Andrew BairdDepartment of Surgery, University of California, San Diego, La Jolla, CA, United States.
Brian P EliceiriDepartment of Surgery, University of California, San Diego, La Jolla, CA, United States.
Allen F RyanDepartment of Otolaryngology, University of California, San Diego, La Jolla, CA, United States.
University of California, San Diego · USGyeongsang National University · KRVA San Diego Healthcare System · US

Funding

Middle ear responses in Otitis MediaR01DC000129 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RYAN, ALLEN F. · 1989 to 2021
$6.8M
Innovative therapy for diseases of the middle earR01DC012595 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RYAN, ALLEN F. · 2012 to 2023
$3.3M
BLR&D Research Career Scientist Award ApplicationIK6BX005224 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI WEBSTER, NICHOLAS J · 2020 to 2025
–
BLRD VA IK6 BX005224NIDCD NIH HHS R01 DC000129NIDCD NIH HHS R01 DC012595
6 · The paper itself

Abstract

Otitis media (OM), the most common disease of childhood, is typically characterized by bacterial infection of the middle ear (ME). Prominent features of OM include hyperplasia of the ME mucosa, which transforms from a monolayer of simple squamous epithelium with minimal stroma into a full-thickness respiratory epithelium in 2-3 days after infection. Analysis of the murine ME transcriptome during OM showed down-regulation of the tumor suppressor gene

Indexed as

augurinbacterial middle ear infectionECRG4growth suppressionNTHi

Identifiers

PMID36092940
PMCPMC9461705
OpenAlexW4293116015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.