Evidence map›Paper›PMID 36092908›Full record

ArticleFrontiers in genetics2022

Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology.

Gautham Vellaichamy, Anya T Amin, Peter Dimitrion, Zaakir Hamzavi, Li Zhou, Indra Adrianto, Qing-Sheng Mi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gautham VellaichamyCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United States.
Anya T AminCollege of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.
Peter DimitrionCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United States.
Zaakir HamzaviCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United States.
Li ZhouCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United States.
Indra AdriantoCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United States.
Qing-Sheng MiCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United States.
Henry Ford Health System · USUniversity of Toledo · USWayne State University · US

Funding

Using whole-exome sequencing to uncover key genetic variants related to Hidradenitis Suppurativa risk in African American and Hispanic population.R01AR078688 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON, MI, QING-SHENG · 2021 to 2025
$4.1M
Uncover the new subsets of epidermal Langerhans cellsR61AR076803 · NIAMS · HENRY FORD HEALTH SYSTEM · PI ADRIANTO, INDRA, MI, QING-SHENG · 2019 to 2020
$746k
Genetic risk of hidradenitis suppurativa in African AmericansR21AR079089 · NIAMS · HENRY FORD HEALTH SYSTEM · PI ADRIANTO, INDRA, MI, QING-SHENG · 2022 to 2023
$520k
Uncover the new subsets of epidermal Langerhans cellsR33AR076803 · NIAMS · HENRY FORD HEALTH SYSTEM · PI ADRIANTO, INDRA, MI, QING-SHENG · 2021 to 2021
$380k
Decoding TGF-beta signaling pathways in skin langerhans cellsR56AI165991 · NIAID · HENRY FORD HEALTH SYSTEM · PI MI, QING-SHENG, ZHOU, LI · 2022 to 2022
$376k
NIAMS NIH HHS R01 AR078688NIAMS NIH HHS R21 AR079089NIAMS NIH HHS R61 AR076803
6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is a multifactorial chronic skin disease characterized by inflammation around the hair follicles commonly affecting intertriginous areas. The underlying pathogenesis of HS and its molecular mechanisms are largely understudied. Genetic studies in families have identified variants within the γ-secretase complex associated with HS; however, no definitive genotype-phenotype correlations have been made. The lack of knowledge regarding the intersection of genetics, immunology and environmental risk factors is a major obstacle to improving treatment for patients with HS. This article provides an overview of the role of race, genetics, and immunology in HS to provide insight into the multiple factors influencing the pathophysiology of HS.

Indexed as

ancestrygamma-secretase complexgeneticshidradenitis suppurativaimmunologyproteomicsracetranscriptomics

Identifiers

PMID36092908
PMCPMC9458948
OpenAlexW4293217333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.