Evidence map›Paper›PMID 36092852›Full record

ArticleJournal of blood medicine2022

Acute Malaria in Malawian Children and Adults is Characterized by Thrombocytopenia That Normalizes in Convalescence.

Wilson Mandala, Alinane Munyenyembe, Innocent Sulani, Monica Soko, Jane Mallewa, Jasmin Hiestand

Open access · goldAbstract read
In one paragraph

Article in Journal of blood medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Wilson MandalaBasic Sciences Department, Kamuzu University of Health Sciences, Blantyre, Malawi.ORCID 0000-0001-9386-9239
Alinane MunyenyembeMalawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Innocent SulaniMalawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.ORCID 0000-0003-4817-1979
Monica SokoMalawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Jane MallewaMedicine Department, Kamuzu University of Health Sciences, Blantyre, Malawi.
Jasmin HiestandMedicine Department, Kamuzu University of Health Sciences, Blantyre, Malawi.
University of Liverpool · GBKamuzu Central Hospital · MW

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: Materials and Methods: We recruited a total of 113 HIV-uninfected children with acute malaria [n=54 with uncomplicated malaria (UCM), n=30 with severe malarial anemia (SMA), n=29 presenting with cerebral malaria (CM)]. We also recruited 42 HIV-uninfected healthy controls. Out of the 113 participants with malaria, 73 (65%) [n=34 (63%) UCM, n=21 (70%) SMA and n=18 (62%) CM] were successfully followed-up one month after treatment. A 5mL peripheral blood sample was collected for platelet count using HMX Haematological Analyzer analysis both at baseline (acute malaria) and at follow-up a month later. Platelet counts were also determined in blood samples of 106 HIV-uninfected adults, 47 of whom presented with UCM and 29 with severe malaria (SM) and these counts were compared to those of 30 healthy controls. Of the malaria cases, platelet counts for 44 UCM and 21 SM were determined again during follow-up a month after treatment. Results: In both children and adults, platelet counts were significantly lower during acute disease compared to the levels in the healthy controls with the lowest levels observed in CM (children) or SM (adults). These lower than normal levels increased close to normal levels a month post treatment. Conclusion:

Indexed as

acute malariachildren and adultsconvalescenceplatelet counts

Identifiers

PMID36092852
PMCPMC9462550
OpenAlexW4294592108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.