Evidence map›Paper›PMID 36092802›Full record

SynthesisFrontiers in aging neuroscience2022

Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis.

Bojun Zhou, Zhisheng Wang, Lianghao Zhu, Gang Huang, Bing Li, Chaofan Chen, Junda Huang, Fuhai Ma, Timon Chengyi Liu

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  12. Chronic Pain and Opioids in the Elderly: Treating the Brain, Not Just the Body.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bojun ZhouSchool of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Zhisheng WangSchool of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Lianghao ZhuSchool of Physical Education, Hubei Business College, Wuhan, China.
Gang HuangSchool of Physical Education, Hunan University of Science and Technology, Xiangtan, China.
Bing LiGraduate School, Guangzhou Sport University, Guangzhou, China.
Chaofan ChenSchool of Physical Education, College of Art and Physical Education, Gangneung-Wonju National University, Gangneung, South Korea.
Junda HuangSchool of Physical Education, Xianyang Normal University, Xianyang, China.
Fuhai MaAcademy of Plateau Science and Sustainability, Qinghai Normal University, Xining, China.
Timon Chengyi LiuSchool of Physical Education and Sports Science, South China Normal University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Emerging evidence suggests that exercise is a simple and effective method for maintaining brain function. Aims: This review evaluates the effects of five physical exercises, including aerobic training (AT), high-intensity interval training (HIIT), combined training (CT), resistance training (RT), and AT+RT, on the serum level of brain-derived neurotrophic factor (BDNF) in healthy and non-healthy populations. Methods: We searched CNKI, PubMed, Embase, Scopus, Medline, Web of Science, and Cochrane Library databases to review randomized controlled studies on exercise interventions for BDNF. Quantitative merging analysis of the resulting data using Bayesian network meta-analysis. Results: The screening and exclusion of the searched literature resulted in the inclusion of 39 randomized controlled trials containing 5 exercise interventions with a total of 2031 subjects. The AT, RT, AT+RT, HIIT, and CT groups (intervention groups) and the CG group (conventional control group) were assigned to 451, 236, 102, 84, 293, and 865 subjects, respectively. The Bayesian network meta-analysis ranked the effect of exercise on BDNF level improvement in healthy and non-healthy subjects as follows: RT > HIIT > CT > AT+RT > AT > CG. Better outcomes were observed in all five intervention groups than in the CG group, with RT having the most significant effect [MD = 3.11 (0.33, 5.76), Conclusions: RT at moderate intensity is recommended for children and older adults in the case of exercise tolerance and is effective in maintaining or modulating BDNF levels for promoting brain health. Systematic Review Registration: https://inplasy.com, INPLASY202250164.

Indexed as

brain-derived neurotrophic factorbrain healthexercise interventiongeometric meannetwork meta-analysisquantitative differencerehabilitation

Identifiers

PMID36092802
PMCPMC9461137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.