Evidence map›Paper›PMID 36092795›Full record

ArticlePulmonary circulation2022

Real-world use of inhaled treprostinil for lung disease-pulmonary hypertension: A protocol for patient evaluation and prescribing.

Shelsey W Johnson, Lauren Finlay, Stephen C Mathai, Ronald H Goldstein, Bradley A Maron

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pulmonary Hypertension: A Contemporary Review.American journal of respiratory and critical care medicine · 2023
    Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Shelsey W JohnsonDepartment of Pulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System Boston Massachusetts USA.ORCID 0000-0002-6297-6389
Lauren FinlayDepartment of Pharmacy VA Boston Healthcare System Boston Massachusetts USA.
Stephen C MathaiDepartment of Pulmonary and Critical Care Medicine Johns Hopkins University, and Johns Hopkins School of Medicine Baltimore Maryland USA.
Ronald H GoldsteinDepartment of Pulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System Boston Massachusetts USA.
Bradley A MaronDepartment of Pulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System Boston Massachusetts USA.ORCID 0000-0002-6784-764X
Boston University · USBrigham and Women's Hospital · USJohns Hopkins University · USVA Boston Healthcare System · US

Funding

BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
Targeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertensionR01HL139613 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Sirano Dhe-Paganon, Bradley Maron · 2018 to 2026
$4.1M
NEDD9-SMAD3, fibrinolysis, and chronic thromboembolic pulmonary hypertensionR01HL153502 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2020 to 2023
$1.7M
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertensionR01HL155096 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL139613NHLBI NIH HHS R01 HL153502NHLBI NIH HHS R01 HL155096NHLBI NIH HHS T32 HL007035
6 · The paper itself

Abstract

Inhaled treprostinil was approved recently for interstitial lung disease-pulmonary hypertension; however, efficacy in "real-world" populations is not known. We designed a protocol and report our experience evaluating 10 patients referred for therapy. Misdiagnosis at presentation was common; ultimately, three patients (30%) were prescribed drug. This protocol offers an opportunity to standardize longitudinal assessment of inhaled treprostinil in clinical practice.

Indexed as

Group 3 pulmonary hypertensioninhaled treprostinilinterstitial lung diseasepulmonary hypertension

Identifiers

PMID36092795
PMCPMC9450844
OpenAlexW4290842221

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.