Evidence map›Paper›PMID 36092690›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022

Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume.

Shraddha Sapkota, Kelsey Erickson, Danielle Harvey, Sarah E Tomaszewski-Farias, John M Olichney, David K Johnson, Brittany N Dugger, Dan M Mungas, Evan Fletcher, Pauline Maillard and 8 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Relationship of Alzheimer's Disease and Related Dementias Plasma Biomarkers With Mobility in Cognitively Unimpaired Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  4. Article
  5. Peripheral risk factors and their role in biomarker-based screening for dementia in the community.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shraddha SapkotaDepartment of Neurology University of California Davis California USA.
Kelsey EricksonDepartment of Pathology and Laboratory Medicine University of California Davis California USA.
Danielle HarveyDepartment of Public Health Sciences University of California Davis California USA.
Sarah E Tomaszewski-FariasDepartment of Neurology University of California Davis California USA.
John M OlichneyDepartment of Neurology University of California Davis California USA.
David K JohnsonDepartment of Neurology University of California Davis California USA.
Brittany N DuggerDepartment of Pathology and Laboratory Medicine University of California Davis California USA.
Dan M MungasDepartment of Neurology University of California Davis California USA.
Evan FletcherDepartment of Neurology University of California Davis California USA.
Pauline MaillardDepartment of Neurology University of California Davis California USA.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases and Department of Population Health Sciences UT Health San Antonio San Antonio Texas USA.
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases and Department of Population Health Sciences UT Health San Antonio San Antonio Texas USA.
Tiffany KautzGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases and Department of Population Health Sciences UT Health San Antonio San Antonio Texas USA.
Danielle ParentDepartment of Pathology and Laboratory Medicine University of Vermont Burlington Vermont USA.
Russell P TracyDepartment of Pathology and Laboratory Medicine University of Vermont Burlington Vermont USA.
Izumi MaezawaDepartment of Pathology and Laboratory Medicine University of California Davis California USA.
Lee-Way JinDepartment of Pathology and Laboratory Medicine University of California Davis California USA.
Charles DeCarliDepartment of Neurology University of California Davis California USA.

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEE-WAY JIN · 2021 to 2026
$25.2M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)RF1AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2018 to 2018
$6.1M
THE UNIVERSITY OF TEXAS HOUSTON STROKE TRAINING PROGRAMT32NS007412 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SAVITZ, SEAN I · 1998 to 2023
$4.6M
Multiethnic Validation of VCID Biomarkers in South TexasU01NS125513 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SATIZABAL, CLAUDIA L · 2023 to 2025
$3.3M
Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE ConsortiumUH3NS100605 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2018 to 2020
$3.0M
Multiethnic Validation of VCID biomarkers in South TexasUF1NS125513 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SATIZABAL, CLAUDIA L · 2021 to 2021
$2.4M
NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072972NIA NIH HHS RF1 AG059421NINDS NIH HHS R01 NS017950NINDS NIH HHS T32 NS007412NINDS NIH HHS U01 NS125513NINDS NIH HHS UF1 NS125513NINDS NIH HHS UH3 NS100605
6 · The paper itself

Abstract

Introduction: We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration. Methods: All participants were recruited from the University of California, Davis-Alzheimer's Disease Research Center ( Results: HV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t-tau and cognitive performance. Discussion: Neurodegeneration as represented with HV selectively mediates the association between key non-invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community-based sample.

Indexed as

Alzheimer's diseaseamyloid β 42/40cognitionhippocampal volumeneurofilament lightplasma biomarkerstotal‐tau

Identifiers

PMID36092690
PMCPMC9434579

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.