Evidence map›Paper›PMID 36092589›Full record

ArticleACS omega2022

Cimetidine-Based Cationic Amphiphiles for In Vitro Gene Delivery Targetable to Colon Cancer.

Shireesha Manturthi, Dwaipayan Bhattacharya, Kalyani Rajesh Sakhare, Kumar Pranav Narayan, Srilakshmi V Patri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shireesha ManturthiDepartment of Chemistry, National Institute of Technology Warangal, Hanamkonda, Telangana 506004, India.
Dwaipayan BhattacharyaDepartment of Biological Science, Bits Pilani-Hyderabad, Hyderabad, Telangana 500078, India.
Kalyani Rajesh SakhareDepartment of Biological Science, Bits Pilani-Hyderabad, Hyderabad, Telangana 500078, India.
Kumar Pranav NarayanDepartment of Biological Science, Bits Pilani-Hyderabad, Hyderabad, Telangana 500078, India.
Srilakshmi V PatriDepartment of Chemistry, National Institute of Technology Warangal, Hanamkonda, Telangana 506004, India.ORCID https://orcid.org/0000-0002-2104-0007
Birla Institute of Technology and Science - Hyderabad Campus · INNational Institute of Technology Warangal · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cimetidine, a histamine-2 (H2) receptor antagonist, has been found to have anticancer properties against a number of cancer-type cells. In this report, we have demonstrated that cimetidine can acts as a hydrophilic domain in cationic lipids and targetable to the gastric system by carrying reporter genes and therapeutic genes through in vitro transfection. Two lipids, namely, Toc-Cim and Chol-Cim consisting cimetidine as the main head group and hydrophobic moieties as alpha-tocopherol or cholesterol, respectively, were designed and synthesized. 1,2-Dioleoyl-

Identifiers

PMID36092589
PMCPMC9453813
OpenAlexW4293230872

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.