Evidence map›Paper›PMID 36092501›Full record

ArticleRegenerative therapy2022

Human umbilical cord mesenchymal stem cell-derived exosomes promote neurological function recovery in rat after traumatic brain injury by inhibiting the activation of microglia and astrocyte.

Lianxu Cui, Wei Luo, Wenkang Jiang, Haomin Li, Junrong Xu, Xiaocui Liu, Bingyun Wang, Jinhui Wang, Guoqiang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  20. Mesenchymal stem cell-derived extracellular vesicles for human diseases.Extracellular vesicles and circulating nucleic acids · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lianxu CuiThe First People's Hospital of Foshan, Foshan, Guangdong Province, 528000, China.
Wei LuoThe First People's Hospital of Foshan, Foshan, Guangdong Province, 528000, China.
Wenkang JiangSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong Province, 528225, China.
Haomin LiThe First People's Hospital of Foshan, Foshan, Guangdong Province, 528000, China.
Junrong XuGuangdong VitaLife Biotech Co., Foshan, Guangdong Province, 528251, China.
Xiaocui LiuGuangdong VitaLife Biotech Co., Foshan, Guangdong Province, 528251, China.
Bingyun WangSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong Province, 528225, China.
Jinhui WangGuangdong VitaLife Biotech Co., Foshan, Guangdong Province, 528251, China.
Guoqiang ChenThe First People's Hospital of Foshan, Foshan, Guangdong Province, 528000, China.
First People's Hospital of Foshan · CNFoshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a serious neurological disorder with increasing worldwide incidence. Emerging evidence has shown a significant therapeutic role of mesenchymal stem cells (MSCs) derived exosomes on traumatic brain injury with broad application prospects as a cell-free therapy. However, a comprehensive understanding of its underlying mechanism remained elusive. In this study, umbilical cord mesenchymal stem cells (UCMSCs)-derived exosomes (UC-MSCs-Exo) were isolated by ultracentrifugation and injected intraventricularly in a rat model of TBI. Our results showed that UC-MSCs-Exo promoted functional recovery and reduced neuronal apoptosis in TBI rats. Moreover, UC-MSCs-Exo inhibited the activation of microglia and astrocytes during brain injury, thereby promoting functional recovery. However, the effect of UC-MSCs-Exo on the content of plasma inflammatory factors in rats was not significant. Collectively our study suggested that UC-MSCs-Exo promotes the recovery of neurological function in TBI rats by inhibiting the activation of microglia and astrocytes, providing a theoretical basis for new therapeutic strategies for central nervous system diseases.

Indexed as

AstrocytesExosomesMicrogliaTraumatic brain injuryUmbilical cord mesenchymal stem cells

Identifiers

PMID36092501
PMCPMC9440059
OpenAlexW4293565925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.