Evidence map›Paper›PMID 36092474›Full record

ArticleAlgorithms2021

Molecular Subtyping and Outlier Detection in Human Disease Using the Paraclique Algorithm.

Ronald D Hagan, Michael A Langston

Open access · goldAbstract read
In one paragraph

Article in Algorithms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ronald D HaganDepartment of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN 37996, USA.
Michael A LangstonDepartment of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN 37996, USA.
University of Tennessee at Knoxville · US

Funding

Data Structures, Algorithms and Tools for Ontological DiscoveryR01AA018776 · NIAAA · JACKSON LABORATORY · PI CHESLER, ELISSA J · 2010 to 2019
$3.9M
Circulating microbiome and premature mortality in hemodialysis patientsR01DK125586 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUMIDA, KEIICHI · 2020 to 2024
$2.8M
HSRD VA I01 HX002680NIAAA NIH HHS R01 AA018776NIDDK NIH HHS R01 DK125586
6 · The paper itself

Abstract

Recent discoveries of distinct molecular subtypes have led to remarkable advances in treatment for a variety of diseases. While subtyping via unsupervised clustering has received a great deal of interest, most methods rely on basic statistical or machine learning methods. At the same time, techniques based on graph clustering, particularly clique-based strategies, have been successfully used to identify disease biomarkers and gene networks. A graph theoretical approach based on the paraclique algorithm is described that can easily be employed to identify putative disease subtypes and serve as an aid in outlier detection as well. The feasibility and potential effectiveness of this method is demonstrated on publicly available gene co-expression data derived from patient samples covering twelve different disease families.

Indexed as

molecular subtypingoutlier detectionparaclique algorithmtranscriptomic data

Identifiers

PMID36092474
PMCPMC9455766
OpenAlexW3129895820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.