Evidence map›Paper›PMID 36092362›Full record

ArticleMolecular therapy. Methods & clinical development2022

Preclinical safety assessment of MV-s-NAP, a novel oncolytic measles virus strain armed with an

Kimberly B Viker, Michael B Steele, Ianko D Iankov, Susanna C Concilio, Arun Ammayappan, Brad Bolon, Nathan J Jenks, Matthew P Goetz, Eleni Panagioti, Mark J Federspiel and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The role and mechanism of neutrophils in oncolytic virus therapy.Experimental biology and medicine (Maywood, N.J.) · 2026
    Review
  5. Article
  6. Harnessing myeloid cells in cancer.Molecular cancer · 2025
    Review
  7. Review
  8. Personalizing Oncolytic Immunovirotherapy Approaches.Molecular diagnosis & therapy · 2024
    Article
  9. Article
  10. Review
  11. Neutrophils in oncolytic virus immunotherapy.Frontiers in immunology · 2024
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kimberly B VikerDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Michael B SteeleDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Ianko D IankovDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Susanna C ConcilioDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Arun AmmayappanDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Brad BolonGEMpath, Inc., Longmont, CO 80501, USA.
Nathan J JenksDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Matthew P GoetzDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Eleni PanagiotiDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Mark J FederspielDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Minetta C LiuDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Kah Whye PengDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Evanthia GalanisDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Mayo Clinic in Arizona · USNewPath Research · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2005 to 2026
$49.9M
Optimizing Delivery of Oncolytic Measles Virus Strains with Cell CarriersR01CA200507 · NCI · MAYO CLINIC ROCHESTER · PI GALANIS, EVANTHIA · 2017 to 2020
$2.3M
NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA200507
6 · The paper itself

Abstract

Despite recent therapeutic advances, metastatic breast cancer (MBC) remains incurable. Engineered measles virus (MV) constructs based on the attenuated MV Edmonston vaccine platform have demonstrated significant oncolytic activity against solid tumors. The

Indexed as

IFNAR KO-CD46Ge mouse modelmeaslesmetastatic breast cancerMV-s-NAPNAPneutrophil activating proteinoncolytic virus

Identifiers

PMID36092362
PMCPMC9437807
OpenAlexW4289080147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.