Evidence map›Paper›PMID 36092349›Full record

ArticleJournal of gastrointestinal oncology2022

Diagnostic and prognostic potential of the novel biomarker nuclear cap binding protein subunit 2 (

He Bu, Ting Cao, Xuesong Li, Yuekun Guo, Jiajia Guo, Yuxin Wang, Yunlong Sun, Donghong Wang

Open access · diamondAbstract read
In one paragraph

Article in Journal of gastrointestinal oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The mCancers · 2023
    Article
  9. Function of TRPC1 in modulating hepatocellular carcinoma progression.Medical oncology (Northwood, London, England) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

He BuDepartment of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Ting CaoInstitute of Pathology of Qiqihar Medical University, Qiqihar, China.
Xuesong LiDepartment of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Yuekun GuoDepartment of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Jiajia GuoDepartment of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Yuxin WangDepartment of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Yunlong SunStaidson Biopharmaceuticals Company Limited, Beijing, China.
Donghong WangDepartment of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Qiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Colon adenocarcinoma (COAD) is an incurable malignancy and the third most common tumor worldwide. Advances in biomarkers screening have greatly contributed to explore the new diagnostic and prognostic biomarkers for the early detection and prognostic of COAD. However, the heterogeneity-specific nature of COAD in patients of different cancer stages, different races, genders and age are still the major challenge to clinical treatment. Methods: Gene expression, copy number (CN), and dependency score (DS) data were obtained from the Cancer Cell Line Encyclopedia (CCLE), and linear regression analyses were performed using R language. We conducted receiver operating characteristic (ROC) curve analysis and compared the area under the ROC curve area under the curve (AUC) values to evaluate the sensitivity and specificity of nuclear cap binding protein subunit 2 ( Results: Through the linear regression analysis of DS, CN, and gene expression, we determined that Conclusions: NCBP2 was the novel diagnostic and prognostic biomarker of in COAD. Our research had implications for the treatment of colon cancer.

Indexed as

Colon adenocarcinoma (COAD)novel biomarkernuclear cap binding protein subunit 2 (NCBP2)

Identifiers

PMID36092349
PMCPMC9459195
OpenAlexW4293213685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.