ArticleIEEE transactions on radiation and plasma medical sciences2022
Development of Ultra-High Dose-Rate (FLASH) Particle Therapy.
Article in IEEE transactions on radiation and plasma medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Expanding dose and dose-rate capabilities of a synchrotron-based pre-clinical proton FLASH irradiation platform.Medical physics · 2026Article
- Lighting up FLASH and beyond: TLD response across four orders of magnitude in proton dose rate.Medical physics · 2026Article
- FLASH effect tissue sparing comparison for X-ray, hadron, and VHEE irradiation modalities.Scientific reports · 2026Article
- Multileaf Faraday cup for beam energy verification in radiation therapy with ultra-high dose-rate electron beams and ion beams.Medical physics · 2026Article
- Review
- Biological effects of conventional and ultra high dose rate radiation in human cells.Scientific reports · 2026Article
- Ultra-high-dose-rate pulsed irradiation and the conditional FLASH effect: dosimetry, multiscale biology, and clinical translation.Frontiers in oncology · 2026Review
- FLASH Radiotherapy in Lung Cancer: Translational Mechanisms, Preclinical Evidence, and Barriers.Cureus · 2026Review
- Pulse-by-pulse ultra-high resolution scintillation imaging of proton FLASH beams produced by a gantry-mounted synchrocyclotron.Physics in medicine and biology · 2025Article
- Commissioning of a gantry-mounted synchrocyclotron for preclinical FLASH studies utilizing spread-out Bragg peaks.Journal of applied clinical medical physics · 2025Article
- Emerging strategies in radiation therapy: promises and challenges of spatial fractionation, ultra-high dose rates, and nanoparticles.Journal of physics D: Applied physics · 2025Review
- Three-dimensional proton FLASH dose rate measurement at high spatiotemporal resolution using a novel multi-layer strip ionization chamber (MLSIC) device.Medical physics · 2025Article
- Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect.Cell death & disease · 2025Article
- Implementation of a proton FLASH platform for pre-clinical studies using a gantry-mounted synchrocyclotron.Physics in medicine and biology · 2025Article
- Characterization of a Time-Resolved, Real-Time Scintillation Dosimetry System for Ultra-High Dose-Rate Radiation Therapy Applications.International journal of radiation oncology, biology, physics · 2025Article
- On the acceptance, commissioning, and quality assurance of electron FLASH units.Medical physics · 2025Article
- Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study.Physics in medicine and biology · 2024Article
- Simultaneous dose and dose rate optimization via dose modifying factor modeling for FLASH effective dose.Medical physics · 2024Article
- Impact of Scattering Foil Composition on Electron Energy Distribution in a Clinical Linear Accelerator Modified for FLASH Radiotherapy: A Monte Carlo Study.Materials (Basel, Switzerland) · 2024Article
- Simulation study of protoacoustics as a real-time in-line dosimetry tool for FLASH proton therapy.Medical physics · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy ion FLASH radiotherapy, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental set-up, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH radiotherapy is discussed along with potential drawbacks when translated into the clinical setting. The final section concludes with further questions that have yet to be answered before safe clinical implementation of FLASH radiotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.