Evidence map›Paper›PMID 36092250›Full record

ArticleMolecular genetics and metabolism reports2022

Generation of GLA-knockout human embryonic stem cell lines to model peripheral neuropathy in Fabry disease.

Christine R Kaneski, John A Hanover, Ulrike H Schueler Hoffman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Molecular genetics and metabolism reports · 2024
    Article
  3. Stem cells and pain.World journal of stem cells · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christine R KaneskiNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
John A HanoverNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ulrike H Schueler HoffmanNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
National Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fabry disease is an X-linked glycolipid storage disorder caused by mutations in the

Indexed as

4-MU, 4-methylumbelliferoneAGA, alpha-galactosidase AAlpha-galactosidaseBDNF, brain-derived neurotrophic factorBRN3A, brain-specific homeobox/POU domain protein 3ACRISPR-Cas9DAPI, 4′,6-diamidino-2-phenylindoleDRG, dorsal root ganglionEDTA, ethylene diamine tetracetic acideGFP, green fluorescent proteinERT, enzyme replacement therapyFabry diseaseGAPDH, glyceraldehyde-3-phosphate dehydrogenaseGb3, globotriaosylceramideGDNF, glia-derived neurotrophic factorGLA, alpha-galactosidase A genehESC, human embryonic stem cellHEX, beta-hexosaminidaseHuman embryonic stem cellsiPSC, induced pluripotent stem cellNeuropathyNGF, nerve growth factorPAM, protospacer adjacent motifPBS, phosphate buffered salineRNP, ribonucleoproteinSensory neuronsSgRNA, single guide RNATNA-alpha, Tumor Necrosis Factor- alphaTRPV1, transient receptor potential vanilloid family-1

Identifiers

PMID36092250
PMCPMC9449667
OpenAlexW4293339590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.