ArticleSociological science2020
Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges.
Article in Sociological science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Prosocial helping behaviors attenuate accelerated cognitive decline driven by APOE ε4.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Interaction Between Genetic Risk and Parental Feeding Practices in the Prediction of Overweight Across Adolescence.Obesity (Silver Spring, Md.) · 2026Article
- Genetic risk for high body mass index before and amidst the obesity epidemic: Cross-cohort analysis of four british birth cohort studies.PLoS genetics · 2026Article
- Associations of vegetarianism with circulating lipids across varying genetic capacity: a cross-sectional Polygenic Score-by-Vegetarianism interaction study in UK Biobank.medRxiv : the preprint server for health sciences · 2026Article
- Association of air pollution with chronic obstructive pulmonary disease: anemia-related outcomes and exploratory genetic susceptibility analyses.Frontiers in medicine · 2026Article
- The Economics and Econometrics of Gene-Environment Interplay.The Review of economic studies · 2026Article
- Assessing Orthogonality in Gene-Environment Interaction Studies Using Polygenic Indices.Behavior genetics · 2026Article
- Methods for modeling gene-environment interplay using polygenic risk scores.Statistical applications in genetics and molecular biology · 2026Review
- Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene-environment interplay with family conflict and parental acceptance.Development and psychopathology · 2025Article
- Polygenic Scores and Environmental Factors in Psychiatric Disorders: Gene-Environment Interaction Analyses Using the iPSYCH Study.Research square · 2025Article
- Hypothesis test of specific parametric structure in a generalized additive model.medRxiv : the preprint server for health sciences · 2025Article
- PIGEON: a statistical framework for estimating gene-environment interaction for polygenic traits.Nature human behaviour · 2025Article
- Evolutionary Trajectories of Consciousness: From Biological Foundations to Technological Horizons.Brain sciences · 2025Review
- Raising the Floor? Genetic Influences on Educational Attainment Through the Lens of the Evolving Swedish Welfare State.Behavior genetics · 2025Article
- Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.Psychological medicine · 2025Article
- Interplay between genetic risk and built neighborhood conditions as predictor of BMI across the transition into adulthood.Obesity (Silver Spring, Md.) · 2025Article
- Associations of polygenic scores and developmental trajectories of externalizing behaviors.Development and psychopathology · 2025Article
- Social Determinants of Health and Lifestyle Risk Factors Modulate Genetic Susceptibility for Women's Health Outcomes.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Joint modeling of gene-environment correlations and interactions using polygenic risk scores in case-control studies.American journal of epidemiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Interest in the study of gene-environment interaction has recently grown due to the sudden availability of molecular genetic data-in particular, polygenic scores-in many long-running longitudinal studies. Identifying and estimating statistical interactions comes with several analytic and inferential challenges; these challenges are heightened when used to integrate observational genomic and social science data. We articulate some of these key challenges, provide new perspectives on the study of gene-environment interactions, and end by offering some practical guidance for conducting research in this area. Given the sudden availability of well-powered polygenic scores, we anticipate a substantial increase in research testing for interaction between such scores and environments. The issues we discuss, if not properly addressed, may impact the enduring scientific value of gene-environment interaction studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.