Evidence map›Paper›PMID 36091919›Full record

ArticleChemical science2022

Switching from ultrafast electron transfer to proton transfer in excited drug-protein complexes upon biotransformation.

Lorena Tamarit, Meryem El Ouardi, Emilio Lence, Inmaculada Andreu, Concepción González-Bello, Ignacio Vayá, Miguel A Miranda

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lorena TamaritDepartamento de Química/Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València Camino de Vera s/n 46022 València Spain mmiranda@qim.upv.es igvapre@qim.upv.es.ORCID https://orcid.org/0000-0001-9615-5004
Meryem El OuardiDepartamento de Química/Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València Camino de Vera s/n 46022 València Spain mmiranda@qim.upv.es igvapre@qim.upv.es.
Emilio LenceCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela Jenaro de la Fuente s/n 15782 Santiago de Compostela Spain concepcion.gonzalez.bello@usc.es.ORCID https://orcid.org/0000-0001-9489-9421
Inmaculada AndreuDepartamento de Química/Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València Camino de Vera s/n 46022 València Spain mmiranda@qim.upv.es igvapre@qim.upv.es.ORCID https://orcid.org/0000-0003-3409-9443
Concepción González-BelloCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela Jenaro de la Fuente s/n 15782 Santiago de Compostela Spain concepcion.gonzalez.bello@usc.es.ORCID https://orcid.org/0000-0001-6439-553X
Ignacio VayáDepartamento de Química/Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València Camino de Vera s/n 46022 València Spain mmiranda@qim.upv.es igvapre@qim.upv.es.ORCID https://orcid.org/0000-0003-1682-9342
Miguel A MirandaDepartamento de Química/Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València Camino de Vera s/n 46022 València Spain mmiranda@qim.upv.es igvapre@qim.upv.es.ORCID https://orcid.org/0000-0002-7717-8750
Hospital Universitari i Politècnic La Fe · ESUniversidade de Santiago de Compostela · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photosensitization by drugs is directly related with the excited species and the photoinduced processes arising from interaction with UVA light. In this context, the ability of gefitinib (GFT), a tyrosine kinase inhibitor (TKI) used for the treatment of a variety of cancers, to induce phototoxicity and photooxidation of proteins has recently been demonstrated. In principle, photodamage can be generated not only by a given drug but also by its photoactive metabolites that maintain the relevant chromophore. In the present work, a complete study of

Identifiers

PMID36091919
PMCPMC9400592
OpenAlexW4289538628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.