Evidence map›Paper›PMID 36091907›Full record

ArticleChemical science2022

Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction.

Aline Delamare, Guillaume Naulet, Brice Kauffmann, Gilles Guichard, Guillaume Compain

Abstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aline DelamareUniv. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB F-33600 Pessac France g.guichard@iecb.u-bordeaux.fr g.compain@iecb.u-bordeaux.fr.
Guillaume NauletUniv. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB F-33600 Pessac France g.guichard@iecb.u-bordeaux.fr g.compain@iecb.u-bordeaux.fr.
Brice KauffmannUniv. Bordeaux, CNRS, INSERM, IECB, UAR 3033 F-33600 Pessac France.ORCID https://orcid.org/0000-0002-2932-3255
Gilles GuichardUniv. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB F-33600 Pessac France g.guichard@iecb.u-bordeaux.fr g.compain@iecb.u-bordeaux.fr.ORCID https://orcid.org/0000-0002-2584-7502
Guillaume CompainUniv. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB F-33600 Pessac France g.guichard@iecb.u-bordeaux.fr g.compain@iecb.u-bordeaux.fr.ORCID https://orcid.org/0000-0002-9556-1016

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The isobutyl side chain is a highly prevalent hydrophobic group in drugs, and it notably constitutes the side chain of leucine. Its replacement by a hexafluorinated version containing two CF

Identifiers

PMID36091907
PMCPMC9400614

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.