Evidence map›Paper›PMID 36091903›Full record

ArticleChemical science2022

Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles.

Jessica E Boles, Charlotte Bennett, Jennifer Baker, Kira L F Hilton, Hiral A Kotak, Ewan R Clark, Yifan Long, Lisa J White, Hin Yuk Lai, Charlotte K Hind and 7 more

Abstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jessica E BolesSchool of Chemistry and Forensics, University of Kent Canterbury CT2 7NH UK J.R.Hiscock@Kent.ac.uk.
Charlotte BennettCancer Research Horizons 2 Redman Place London E20 1JQ UK Mark.Charles@cancer.org.uk.
Jennifer BakerCancer Research Horizons 2 Redman Place London E20 1JQ UK Mark.Charles@cancer.org.uk.
Kira L F HiltonSchool of Chemistry and Forensics, University of Kent Canterbury CT2 7NH UK J.R.Hiscock@Kent.ac.uk.
Hiral A KotakChemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK cally.haynes@ucl.ac.uk.ORCID https://orcid.org/0000-0002-1080-3494
Ewan R ClarkSchool of Chemistry and Forensics, University of Kent Canterbury CT2 7NH UK J.R.Hiscock@Kent.ac.uk.ORCID https://orcid.org/0000-0001-7287-2631
Yifan LongChemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK cally.haynes@ucl.ac.uk.
Lisa J WhiteSchool of Chemistry and Forensics, University of Kent Canterbury CT2 7NH UK J.R.Hiscock@Kent.ac.uk.
Hin Yuk LaiChemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK cally.haynes@ucl.ac.uk.
Charlotte K HindResearch and Evaluation Porton Down, UKHSA, Porton Down Salisbury SP4 0JG UK.
J Mark SuttonResearch and Evaluation Porton Down, UKHSA, Porton Down Salisbury SP4 0JG UK.
Michelle D GarrettSchool of Biosciences, University of Kent Canterbury CT2 7NJ UK.
Anne CheastyCancer Research Horizons 2 Redman Place London E20 1JQ UK Mark.Charles@cancer.org.uk.
Jose L Ortega-RoldanSchool of Biosciences, University of Kent Canterbury CT2 7NJ UK.ORCID https://orcid.org/0000-0002-6316-4390
Mark CharlesCancer Research Horizons 2 Redman Place London E20 1JQ UK Mark.Charles@cancer.org.uk.
Cally J E HaynesChemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK cally.haynes@ucl.ac.uk.ORCID https://orcid.org/0000-0003-4262-8560
Jennifer R HiscockSchool of Chemistry and Forensics, University of Kent Canterbury CT2 7NH UK J.R.Hiscock@Kent.ac.uk.ORCID https://orcid.org/0000-0002-1406-8802

Funding

Medical Research Council MR/T020415/1
6 · The paper itself

Abstract

The rise of antimicrobial resistance remains one of the greatest global health threats facing humanity. Furthermore, the development of novel antibiotics has all but ground to a halt due to a collision of intersectional pressures. Herein we determine the antimicrobial efficacy for 14 structurally related supramolecular self-associating amphiphiles against clinically relevant Gram-positive methicillin resistant

Identifiers

PMID36091903
PMCPMC9400670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.