ArticleFrontiers in pharmacology2022
Application of metabolomics and network analysis to reveal the ameliorating effect of four typical "hot" property herbs on hypothyroidism rats.
Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Study on the Warm Property Mechanism of Pro- HS and Its Separated Fractions Based on Metabolomics.Biomedical chromatography : BMC · 2026Article
- Exploring the Comprehensive Treatment of Hashimoto's Thyroiditis with Traditional Chinese Medicine from the Perspective of Modern Medicine.Therapeutics and clinical risk management · 2026Review
- The Mechanism Exploration of Traditional Chinese Medicine's "Different Treatments for Same Disease" Concept in Osteoporosis Therapy: A Serum Metabolomics Study.Journal of cellular and molecular medicine · 2025Article
- Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical "hot" herbs on hypothyroidism.Journal of pharmaceutical analysis · 2025Article
- Exploring Genetic Markers for Cold-Heat Patterns: Integrating Traditional Medicine With Modern Genomic Research.Genetics research · 2025Article
- Article
- Metabolomic profile of patients on levothyroxine treatment for hypothyroidism.European thyroid journal · 2023Article
- Advancing herbal medicine: enhancing product quality and safety through robust quality control practices.Frontiers in pharmacology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herbs with a "hot" properties are frequently used to treat cold symptoms in TCM. However, the underlying mechanisms of the herbs with "hot" properties on hypothyroidism have not been investigated. This study aimed to explore four typical "hot" and "cold" property herb on hypothyroidism. Firstly, the difference efficacy between the four typical "hot" property herbs and the four typical "cold" property herbs was assessed by physical signs, thyroid function, and the metabolic profile using multivariate statistical analysis. The influence of the four typical "hot" property herbs on hypothyroidism was validated pathologically. The impact mechanism of the four typical "hot" property herbs on hypothyroidism was investigated through a metabolomics method combined with network analysis. Na
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