Evidence map›Paper›PMID 36091489›Full record

ArticleThe journal of allergy and clinical immunology. Global2022

Prenatal exposure to Hurricane Maria is associated with an altered infant nasal microbiome.

Sandra Lee, Ai Zhang, Midnela Acevedo Flores, David de Ángel Solá, Lijuan Cao, Benjamin Bolanos-Rosero, Leran Wang, Filipa Godoy-Vitorino, Nicolás Rosario Matos, Leyao Wang

Abstract read
In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Strengthening Integrative Microbiome Research Through Regional Leadership.International journal of environmental research and public health · 2025
    Article
  2. Article
  3. Extreme Weather Events and Asthma.Immunology and allergy clinics of North America · 2024
    Review
  4. Infants exposedmSphere · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sandra LeeDepartment of Medicine, Division of Allergy and Immunology.
Ai ZhangDepartment of Medicine, Division of Allergy and Immunology.
Midnela Acevedo FloresSan Juan City Hospital Research Unit, Department of Pediatrics and Obstetrics and Gynecology, San Juan Hospital.
David de Ángel SoláDepartment of Pediatrics, Yale School of Medicine, New Haven.
Lijuan CaoDepartment of Medicine, Division of Allergy and Immunology.
Benjamin Bolanos-RoseroDepartment of Microbiology and Medical Zoology, School of Medicine, University of Puerto Rico, San Juan.
Leran WangDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University in St Louis School of Medicine.
Filipa Godoy-VitorinoDepartment of Microbiology and Medical Zoology, School of Medicine, University of Puerto Rico, San Juan.
Nicolás Rosario MatosSan Juan City Hospital Research Unit, Department of Pediatrics and Obstetrics and Gynecology, San Juan Hospital.
Leyao WangDepartment of Medicine, Division of Allergy and Immunology.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Role of dysbiotic commensal bacteria in modulating airway inflammation in a mouse model with human lung immune systemR21AI139649 · NIAID · WASHINGTON UNIVERSITY · PI SHAN, LIANG, WANG, LEYAO · 2019 to 2020
$431k
NCATS NIH HHS UL1 TR002345NIAID NIH HHS R21 AI139649
6 · The paper itself

Abstract

Background: Prenatal adverse exposures have been associated with increased risks of development of respiratory diseases in children. The infant nasal microbiome is an important mechanism and indicator. Objective: Our aim was to characterize and compare the nasal microbiome of infants who were Methods: We recruited 63 vaginally born infants, 29 of whom were in the exposure group and 34 of whom were in the control group. Nasal swab samples were collected and analyzed by using 16S ribosomal RNA gene sequencing at the community and taxon levels, respectively. Results: Infants in the exposure group were more likely to harbor a Conclusion: Infants who were exposed to Hurricane Maria during gestation had an altered nasal microbiome, with a higher prevalence of environmental bacteria. More research is needed to evaluate the long-term impacts of extreme weather events occurring in the prenatal stage on a child's nasal microbiome and respiratory health.

Indexed as

asthmadisasterextreme weather eventhurricaneinfant nasal microbiomein uteronasal swabPrenatal maternalrespiratory infectionupper airway bacteria

Identifiers

PMID36091489
PMCPMC9461092

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.