Evidence map›Paper›PMID 36091374›Full record

ArticleFrontiers in physiology2022

Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep.

J Stremming, A White, A Donthi, D G Batt, B Hetrick, E I Chang, S R Wesolowski, M B Seefeldt, C E McCurdy, P J Rozance and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

J StremmingDepartment of Pediatrics, Perinatal Research Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
A WhiteDepartment of Pediatrics, Perinatal Research Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
A DonthiGates Biomanufacturing Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
D G BattGates Biomanufacturing Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
B HetrickDepartment of Human Physiology, University of Oregon, Eugene, OR, United States.
E I ChangDepartment of Pediatrics, Perinatal Research Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
S R WesolowskiDepartment of Pediatrics, Perinatal Research Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
M B SeefeldtGates Biomanufacturing Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
C E McCurdyDepartment of Human Physiology, University of Oregon, Eugene, OR, United States.
P J RozanceDepartment of Pediatrics, Perinatal Research Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
L D BrownDepartment of Pediatrics, Perinatal Research Facility, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
University of Colorado Anschutz Medical Campus · USUniversity of Oregon · US

Funding

Regulation of Fetal Skeletal Muscle Growth in IUGRR01HD079404 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Laura Davidson Brown · 2015 to 2026
$4.7M
UV-visible HPLC with PCX Pinnacle post column reaction moduleS10OD023553 · OD · UNIVERSITY OF COLORADO DENVER · PI BROWN, LAURA DAVIDSON · 2017 to 2017
$98k
6 · The paper itself

Abstract

IGF-1 is a critical fetal growth-promoting hormone. Experimental infusion of an IGF-1 analog, human recombinant LR3 IGF-1, into late gestation fetal sheep increased fetal organ growth and skeletal muscle myoblast proliferation. However, LR3 IGF-1 has a low affinity for IGF binding proteins (IGFBP), thus reducing physiologic regulation of IGF-1 bioavailability. The peptide sequences for LR3 IGF-1 and sheep IGF-1 also differ. To overcome these limitations with LR3 IGF-1, we developed an ovine (sheep) specific recombinant IGF-1 (oIGF-1) and tested its effect on growth in fetal sheep. First, we measured

Indexed as

fetal growthIGF-1 signalingIGF binding proteinmyoblastskeletal muscle

Identifiers

PMID36091374
PMCPMC9452821
OpenAlexW4293224939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.