ArticleFrontiers in physiology2022
Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- 1H-NMR-based metabolomics reveals that prior exercise modulates metabolic changes in the cerebral cortex and hippocampus in sleep-deprived mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- A Two-Hit Model of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed by Sleep Fragmentation.Life (Basel, Switzerland) · 2025Article
- CCPA: cloud-based, self-learning modules for consensus pathway analysis using GO, KEGG and Reactome.Briefings in bioinformatics · 2024Article
- Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation.Frontiers in physiology · 2024Article
- Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats.Life (Basel, Switzerland) · 2023Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
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Abstract
NASA's planned mission to Mars will result in astronauts being exposed to ∼350 mSv/yr of Galactic Cosmic Radiation (GCR). A growing body of data from ground-based experiments indicates that exposure to space radiation doses (approximating those that astronauts will be exposed to on a mission to Mars) impairs a variety of cognitive processes, including cognitive flexibility tasks. Some studies report that 33% of individuals may experience severe cognitive impairment. Translating the results from ground-based rodent studies into tangible risk estimates for astronauts is an enormous challenge, but it would be germane for NASA to use the vast body of data from the rodent studies to start developing appropriate countermeasures, in the expectation that some level of space radiation (SR) -induced cognitive impairment could occur in astronauts. While some targeted studies have reported radiation-induced changes in the neurotransmission properties and/or increased neuroinflammation within space radiation exposed brains, there remains little information that can be used to start the development of a mechanism-based countermeasure strategy. In this study, we have employed a robust label-free mass spectrometry (MS) -based untargeted quantitative proteomic profiling approach to characterize the composition of the medial prefrontal cortex (mPFC) proteome in rats that have been exposed to 15 cGy of 600 MeV/n
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