Evidence map›Paper›PMID 36091034›Full record

ArticleFrontiers in immunology2022

Anti-factor H antibody and its role in atypical hemolytic uremic syndrome.

Rupesh Raina, Guneive Mangat, Gordon Hong, Raghav Shah, Nikhil Nair, Brian Abboud, Sumedha Bagga, Sidharth Kumar Sethi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Updates in atypical hemolytic syndrome.Current opinion in pediatrics · 2026
    Review
  3. Article
  4. Review
  5. Long-term outcome and management of complement-mediated thrombotic microangiopathy/aHUS.Hematology. American Society of Hematology. Education Program · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Kidney diseases.Immunological reviews · 2023
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Rupesh RainaDepartment of Nephrology, Akron Children's Hospital, Akron, OH, United States.
Guneive MangatDepartment of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, United States.
Gordon HongDepartment of Medicine, Northeast Ohio Medical University, Rootstown, OH, United States.
Raghav ShahDepartment of Medicine, Ohio States University, Columbus, OH, United States.
Nikhil NairDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Brian AbboudDepartment of Medicine, Northeast Ohio Medical University, Rootstown, OH, United States.
Sumedha BaggaQuestrom School of Business, Boston University, Boston, MA, United States.
Sidharth Kumar SethiPaediatric Nephrology & Paediatric Kidney Transplantation, Kidney and Urology Institute, Medanta, The Medicity Hospital, Gurgaon, India.
Northeast Ohio Medical University · USAkron Children's Hospital · USAkron General Medical Center · USBoston University · USMedanta The Medicity · INThe Ohio State University · USUniversity School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical hemolytic uremic syndrome (aHUS) an important form of a thrombotic microangiopathy (TMA) that can frequently lead to acute kidney injury (AKI). An important subset of aHUS is the anti-factor H associated aHUS. This variant of aHUS can occur due to deletion of the complement factor H genes,

Indexed as

Acute Kidney InjuryAtypical Hemolytic Uremic SyndromeComplement System ProteinsAntibodiesBlood ProteinsComplement C3b Inactivator ProteinsComplement Factor HHumansPlasma ExchangeAntibodiesBlood ProteinsCFHR1 protein, humanCFHR3 protein, humanComplement C3b Inactivator ProteinsComplement Factor HComplement System ProteinsaHUSanti-factor H antibodyatypical hemolytic uremic syndromefactor Hpediatric

Identifiers

PMID36091034
PMCPMC9448717
OpenAlexW4292850278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.