Evidence map›Paper›PMID 36090950›Full record

ArticleChemPhotoChem2020

Activating Acid-Sensing Ion Channels with Photoacid Generators.

Xinglei Liu, Karthik Sambath, Lauren Hutnik, Jianyang Du, Kevin D Belfield, Yuanwei Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemPhotoChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xinglei LiuDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr. Blvd. Newark NJ 07102 (USA).
Karthik SambathDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr. Blvd. Newark NJ 07102 (USA).
Lauren HutnikDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr. Blvd. Newark NJ 07102 (USA).
Jianyang DuDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis TN 38163 (USA).
Kevin D BelfieldDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr. Blvd. Newark NJ 07102 (USA).
Yuanwei ZhangDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr. Blvd. Newark NJ 07102 (USA).
New Jersey Institute of Technology · USUniversity of Tennessee Health Science Center · US

Funding

CO2 inhalation enhances the lability of fear memoryR01MH113986 · NIMH · UNIVERSITY OF TOLEDO · PI DU, JIANYANG · 2018 to 2022
$1.8M
NIMH NIH HHS R01 MH113986
6 · The paper itself

Abstract

Acid-sensing ion channels (ASICs), present in both central and peripheral neurons, respond to changes in extracellular protons. They play important roles in many symptoms and diseases, such as pain, ischemic stroke and neurodegenerative diseases. Herein, we report a novel approach to activate ASICs with the precision of light using organic photoacid generators (PAGs), which are molecules that release H

Indexed as

acid-sensing ion channelsbioimagingcalcium influxfluorescence imagingphotoacid generatorphotoactivation

Identifiers

PMID36090950
PMCPMC9455902
OpenAlexW3057937019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.