ArticleCerebral cortex communications2022
Functional connectivity of the medial prefrontal cortex related to mindreading abilities.
Article in Cerebral cortex communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Narcissistic and Antisocial Personality Traits Are Both Encoded in the Triple Network: Connectomics Evidence.Psychophysiology · 2025Article
- Cortical areas associated to higher cognition drove primate brain evolution.Communications biology · 2025Article
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6 authors.
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Abstract
The medial prefrontal cortex is a key region of mindreading belonging to the mentalizing system, a set of brain areas underlying mental state inference based on reasoning on social concepts. The aim of this study was to characterize the functional connectivity between regions involved in mindreading and to highlight the processes it underpins, focusing on the dorsal and ventral parts of the medial prefrontal cortex. We analyzed resting-state functional magnetic resonance imaging of 56 healthy volunteers, to study the relationship between mindreading abilities and functional connectivity of the medial prefrontal cortex. Cognitive mindreading performances were correlated with connectivity between the medial prefrontal cortex and frontal regions involved in the regulation of the salience of one's own mental contents, with a distinction between the dorsal part connected to regions subtending inhibition processes and the ventral part to emotional regions. Affective mindreading performances were negatively correlated with negative connectivity of the ventro- and dorsomedial prefrontal cortex with sensorimotor regions belonging to the mirror neuron system subtending the simulation of mental states. These findings suggested a role of the medial prefrontal cortex to decrease the salience of one's own mental content and in the antisynchronous interaction between the mentalizing and mirror neurons systems.
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