Evidence map›Paper›PMID 36090393›Full record

ArticleRSC advances2022

On-demand electrochemically controlled compound release from an ultrasonically powered implant.

Max L Wang, Christian F Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P Annes, Richard N Zare, Amin Arbabian

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. A Wireless Implantable Closed-Loop Electrochemical Drug Delivery System.IEEE transactions on biomedical circuits and systems · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. The Alphabet of Nanostructured Polypyrrole.Materials (Basel, Switzerland) · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Max L WangDepartment of Electrical Engineering, Stanford University Stanford CA USA arbabian@stanford.edu.ORCID https://orcid.org/0000-0003-0261-2142
Christian F ChamberlayneDepartment of Chemistry, Stanford University Stanford CA USA.ORCID https://orcid.org/0000-0001-8589-5074
Haixia XuDepartment of Medicine, Division of Endocrinology, Stanford University Stanford CA USA.
Mohammad MofidfarDepartment of Chemistry, Stanford University Stanford CA USA.ORCID https://orcid.org/0000-0002-7160-8967
Spyridon BaltsaviasDepartment of Electrical Engineering, Stanford University Stanford CA USA arbabian@stanford.edu.ORCID https://orcid.org/0000-0003-4833-7705
Justin P AnnesDepartment of Medicine, Division of Endocrinology, Stanford University Stanford CA USA.ORCID https://orcid.org/0000-0001-8431-3589
Richard N ZareDepartment of Chemistry, Stanford University Stanford CA USA.ORCID https://orcid.org/0000-0001-5266-4253
Amin ArbabianDepartment of Electrical Engineering, Stanford University Stanford CA USA arbabian@stanford.edu.
Stanford University · US

Funding

The Role of Adenosine Kinase in Controlling Beta-Cell RegenerationR01DK101530 · NIDDK · STANFORD UNIVERSITY · PI ANNES, JUSTIN PIERCE · 2015 to 2024
$3.8M
A Wireless, Implantable Microdevice for Closed-Loop Drug Delivery to Prevent the Morbidity of Diabetes Therapy-Induced HypoglycemiaR01EB025867 · NIBIB · STANFORD UNIVERSITY · PI ARBABIAN, AMIN · 2018 to 2021
$2.2M
Development of Beta-Cell-Targeted Regenerative Therapeutics Using A Novel Prodrug StrategyR01DK119955 · NIDDK · STANFORD UNIVERSITY · PI ANNES, JUSTIN PIERCE · 2019 to 2023
$2.1M
In vivo Wireless Sensors for Gut Redox Monitoring to Understand Host and Microbe PhysiologyR21AI163489 · NIAID · STANFORD UNIVERSITY · PI ARBABIAN, AMIN · 2021 to 2022
$434k
NIAID NIH HHS R21 AI163489NIBIB NIH HHS R01 EB025867NIDDK NIH HHS R01 DK101530NIDDK NIH HHS R01 DK119955
6 · The paper itself

Abstract

On-demand drug delivery systems are promising for a wide range of therapeutic applications. When combined with wireless implants for controlled drug delivery, they can reduce overall dosage and side effects. Here, we demonstrate release of fluorescein from a novel on-demand release system for negatively charged compounds. The release system is based on a modified electroresponsive polypyrrole nanoparticulate film designed to minimize ion exchange with the stored compound - a major passive leakage mechanism. We further designed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system

Identifiers

PMID36090393
PMCPMC9382542
OpenAlexW4292260559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.