ArticleThe World Allergy Organization journal2022
Negative impact of penicillin allergy labels on antibiotic use in hospitalized patients in Chinese Mainland.
Article in The World Allergy Organization journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Penicillin Allergy Testing and Delabeling for Patients Who Are Prescribed Penicillin: A Systematic Review for a World Health Organization Guideline.Clinical reviews in allergy & immunology · 2024Pooled it
- Association between penicillin allergy labels and serious adverse events in hospitalized patients: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Epidemiology of penicillin allergy labels in a general Swedish population.The journal of allergy and clinical immunology. Global · 2026Article
- Knowledge, attitudes and practices of clinicians in Shenzhen regarding pediatric streptococcal pharyngitis diagnosis and treatment.Frontiers in cellular and infection microbiology · 2026Article
- Reported penicillin allergy in Israel: Clinical outcomes and antibiotic costs in a nationwide population-based cohort study.The journal of allergy and clinical immunology. Global · 2025Article
- Antibiotic Prescribing for Cellulitis in the Absence of Penicillin-Cephalosporin Cross-Reactivity Alerts: A Retrospective Study.Pharmacology research & perspectives · 2025Article
- Penicillin Allergy in China: Consequences of Inappropriate Skin Testing Practices and Policies.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- Trends of antibiotic use for acute upper respiratory infections in Chinese emergency departments and the impact of COVID-19: a cross-sectional study.Antimicrobial resistance and infection control · 2025Article
- Evaluation of outpatient clindamycin prescriptions across a large military healthcare network.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- [A multicenter clinical study on the incidence and influencing factors of cephalosporin-induced anaphylaxis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Evaluation of appropriateness of antibiotic prescribing in primary healthcare institutions in China using proxy indicator.The Lancet regional health. Western Pacific · 2024Article
- Penicillin or cephalosporin antibiotic allergy label: Influence on length of stay and hospital readmission.The journal of allergy and clinical immunology. Global · 2024Article
- Appropriate use of antibiotics for acute respiratory infections at primary healthcare facilities in China: a nationwide cross-sectional study from 2017 to 2019.The Lancet regional health. Western Pacific · 2023Article
- Differences in beta-lactam and penicillin allergy: Beyond the West and focusing on Asia-Pacific.Frontiers in allergy · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Penicillin allergy labels have gained increasing global attention. However, to date, there are no data on the influence of penicillin allergy labels on patients in Chinese mainland. Methods: This retrospective study reviewed the electronic health record (EHR) of hospitalized patients between June 1, 2018 and May 31, 2019. Patients with a penicillin allergy record were included in the allergy group. Every allergy patient was matched with 4 control patients by using propensity score-based matching to make sure the following were balanced: age, sex, date of admission, and the main diagnosis. We estimated the prevalence of penicillin allergy labels and compared the antibiotic prescription patterns and other clinical outcomes between the 2 groups. Results: A total of 5691 patients and 22 585 patients were included in the allergy group and control group, respectively. The prevalence of penicillin allergy labels among the hospitalized patients in this study was 4.00%. Compared to the control group, significantly fewer patients in the allergy group were prescribed penicillins and most cephalosporins, while a larger proportion of allergy patients received clindamycin (10.02% vs 5.41%, p < 0.001) and some higher-class antibiotics, such as monobactams (1.81% vs 0.54%, p < 0.001), carbapenems (5.80% vs 4.98%, p = 0.014), macrolides (0.60% vs 0.25%, p < 0.001), and quinolones (17.62% vs 12.40%, p < 0.001). Allergy patients also had longer hospital stays and a greater need to consult infection specialists. Conclusion: The prevalence of penicillin allergy labels was 4.00% in Chinese hospitalized patients. Penicillin allergy labels could cause irrational antibiotic prescribing, prolonged hospital stays, and greater consultation needs.
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