Evidence map›Paper›PMID 36090237›Full record

ArticleInternational journal of MS care

Improving Detection of Change in Motor Functioning in Multiple Sclerosis Using Video-Assisted Composite Measures.

Ka-Hoo Lam, Caspar E P van Munster, Marcus D'Souza, Saskia Steinheimer, Christian P Kamm, Jessica Burggraaff, Matthew Johnson, Yordan Zaykov, Jonas Dorn, Frank Dahlke and 3 more

Open access · diamondAbstract read
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In one paragraph

Article in International journal of MS care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Ka-Hoo LamDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (CEPvM, K-HL, JB, JK, BU).
Caspar E P van MunsterDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (CEPvM, K-HL, JB, JK, BU).ORCID https://orcid.org/0000-0001-8701-5413
Marcus D'SouzaNeurologic Clinic and Polyclinic, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland (MD, LK).
Saskia SteinheimerDepartment of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland (SS, CPK).
Christian P KammDepartment of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland (SS, CPK).
Jessica BurggraaffDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (CEPvM, K-HL, JB, JK, BU).
Matthew JohnsonMicrosoft Research UK, Cambridge, UK (MJ, YZ).
Yordan ZaykovMicrosoft Research UK, Cambridge, UK (MJ, YZ).
Jonas DornNovartis Pharma AG, Basel, Switzerland (JD, FD).
Frank DahlkeNovartis Pharma AG, Basel, Switzerland (JD, FD).
Ludwig KapposNeurologic Clinic and Polyclinic, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland (MD, LK).
Joep KillesteinDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (CEPvM, K-HL, JB, JK, BU).
Bernard UitdehaagDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (CEPvM, K-HL, JB, JK, BU).
Amsterdam Neuroscience · NLMicrosoft Research (United Kingdom) · GBNovartis (Switzerland) · CHUniversity Hospital of Basel · CHLuzerner Kantonsspital · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessing motor functioning is important to monitor the disease course of multiple sclerosis (MS). Video-assisted rating of classic neurologic tests and activities of daily living may improve the detection of changes in motor functioning. We investigated the value of using video-assisted composite measures for the detection of changes in mobility and upper extremity function (UEF).

methodsForty-three patients with MS were recorded performing motor function tests before and during treatment with fampridine. Patients were classified as improved or not improved on mobility composite (MOB-COM) and UEF composite (UEF-COM) measures based on neurologists' ratings of the tests. The proportional agreements between the composite measures and the conventional measures-the Timed 25-Foot Walk test (T25FW) and the Nine-Hole Peg Test (NHPT)-were determined and compared with patient-perceived improvement, which was determined using patient-reported ratings of changes in mobility and UEF.

resultsAgreement between MOB-COM and T25FW was 79.5%, and agreement between UEF-COM and NHPT was 82.1%. Twenty-six of 39 patients (66.7%) reported mobility improvement; 6 of these reports were confirmed by both T25FW and MOB-COM, 4 were confirmed by T25FW only, and 2 were confirmed by MOB-COM only. For UEF, 13 of 39 patients (33.3%) reported improvement; 3 of these were confirmed by the NHPT and 3 were confirmed by the UEF-COM.

conclusionsCompared with the conventional NHPT measure, the video-assisted composite measure of UEF detected additional patient-perceived improvement. This was less evident for mobility measures. Video-assisted composite measures may enhance the detection of treatment effects in MS clinical practice and trials.

Indexed as

clinical assessmentmultiple sclerosisrehabilitationupper extremity functionvideo-assisted

Identifiers

PMID36090237
PMCPMC9461716
OpenAlexW4283164144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.