Evidence map›Paper›PMID 36090221›Full record

ArticleHeliyon2022

Transplantation of IGF-1-induced BMSC-derived NPCs promotes tissue repair and motor recovery in a rat spinal cord injury model.

Putri Nur Hidayah Al-Zikri, Tee Jong Huat, Amir Ali Khan, Azim Patar, Mohammed Faruque Reza, Fauziah Mohamad Idris, Jafri Malin Abdullah, Hasnan Jaafar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Putri Nur Hidayah Al-ZikriDepartment of Pathology, School of Medical Sciences, University Sains Malaysia, Kelantan, Malaysia.
Tee Jong HuatDepartment of Biological Sciences, National University of Singapore 117543, Singapore.
Amir Ali KhanDepartment of Applied Biology, College of Sciences, University of Sharjah, Sharjah, P. O. Box 27272, United Arab Emirates.
Azim PatarDepartment of Neurosciences, School of Medical Sciences, University Sains Malaysia, Kelantan, Malaysia.
Mohammed Faruque RezaDepartment of Neurosciences, School of Medical Sciences, University Sains Malaysia, Kelantan, Malaysia.
Fauziah Mohamad IdrisDepartment of Medical Microbiology, School of Medical Sciences, University Sains Malaysia, Kelantan, Malaysia.
Jafri Malin AbdullahDepartment of Neurosciences, School of Medical Sciences, University Sains Malaysia, Kelantan, Malaysia.
Hasnan JaafarDepartment of Pathology, School of Medical Sciences, University Sains Malaysia, Kelantan, Malaysia.
Universiti Sains Malaysia · MYUniversity of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) have therapeutic potential for spinal cord injury (SCI). We have shown that insulin-like growth factor 1 (IGF-1) enhances the cellular proliferation and survivability of BMSCs-derived neural progenitor cells (NPCs) by downregulating miR-22-3p. However, the functional application of BMSCs-derived NPCs has not been investigated fully. In this study, we demonstrate that knockdown of endogenous miR-22-3p in BMSCs-derived NPCs upregulates

Indexed as

Cell therapyGrowth factorMesenchymal stem cellmicroRNANeural differentiationSpinal cord injury

Identifiers

PMID36090221
PMCPMC9449758
OpenAlexW4292849301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.