Evidence map›Paper›PMID 36090026›Full record

ArticleFrontiers in molecular biosciences2022

Using CRISPR/Cas9 genome editing in human iPSCs for deciphering the pathogenicity of a novel

Robin A Pilz, Dariush Skowronek, Motaz Hamed, Anja Weise, Elisabeth Mangold, Alexander Radbruch, Torsten Pietsch, Ute Felbor, Matthias Rath

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Endothelial Differentiation ofInternational journal of molecular sciences · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Robin A PilzDepartment of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Dariush SkowronekDepartment of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Motaz HamedDepartment of Neurosurgery, University Hospital Bonn, Bonn, Germany.
Anja WeiseInstitute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Elisabeth MangoldInstitute of Human Genetics, Medical Faculty and University Hospital Bonn, University of Bonn, Bonn, Germany.
Alexander RadbruchDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany.
Torsten PietschInstitute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, Bonn, Germany.
Ute FelborDepartment of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Matthias RathDepartment of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Universitätsmedizin Greifswald · DEUniversity Hospital Bonn · DEUniversity of Bonn · DEFriedrich Schiller University Jena · DEUniversität Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral cavernous malformations are clusters of aberrant vessels that can lead to severe neurological complications. Pathogenic loss-of-function variants in the

Indexed as

cerebral cavernous malformationCRISPR/Cas9induced pluripotent stem cellstranscription start sitevariant of unknown clinical significance

Identifiers

PMID36090026
PMCPMC9453596
OpenAlexW4293091076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.