ArticleThe EMBO journal1987
Multiple c-myb transcript cap sites are variously utilized in cells of mouse haemopoietic origin.
Article in The EMBO journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways.Nature communications · 2026Article
- MYB as a Critical Transcription Factor and Potential Therapeutic Target in AML.Advances in experimental medicine and biology · 2024Review
- Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease.Clinical and experimental nephrology · 2007Review
- Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells.Clinical and experimental nephrology · 2005Review
- c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis.Molecular and cellular biology · 2001Article
- Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo.The Journal of clinical investigation · 1998Article
- A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.The EMBO journal · 1993Article
- Nucleotide preferences in sequence-specific recognition of DNA by c-myb protein.Nucleic acids research · 1991Article
- Characterization of the sequence-specific interaction of mouse c-myb protein with DNA.The EMBO journal · 1990Article
- Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene.Nucleic acids research · 1989Article
- Hematopoietic lineage-specific heterogeneity in the 5'-terminal region of the chicken proto-myb transcript.Molecular and cellular biology · 1989Article
- Transcription of the chicken myb proto-oncogene starts within a CpG island.Nucleic acids research · 1989Article
- Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.Molecular and cellular biology · 1989Article
- Structural organization of upstream exons and distribution of transcription start sites in the chicken c-myb gene.Molecular and cellular biology · 1989Article
- Nucleotide sequence of chicken myb proto-oncogene promoter region: detection of an evolutionarily conserved element.Nucleic acids research · 1988Article
- Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Expression of the c-myb and c-myc genes is regulated independently in differentiating mouse erythroleukemia cells by common processes of premature transcription arrest and increased mRNA turnover.Molecular and cellular biology · 1988Article
- Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.The EMBO journal · 1988Article
- Alternative internal splicing in c-myb RNAs occurs commonly in normal and tumor cells.The EMBO journal · 1987Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mouse c-myb gene transcripts in various cells of haemopoietic origin were analysed using S1 nuclease and RNase mapping techniques and by Northern blotting. It was found that the prevalent 3.8-kb c-myb mRNA present in thymocytes, T cell leukaemias, myelomonocytic leukaemias, erythroleukaemias and myeloid stem cells was initiated at several cap sites mapping within a region 97-244 bp upstream from the protein coding sequence. Utilization of additional cap sites mapping further upstream was also observed in certain cells, most notably thymocytes, and this gave rise to RNA species (4.3-5.6 kb) larger than the presumptive mRNA. In contrast, myeloma cell c-myb transcripts, which are much less abundant than those in more immature haemopoietic cells, were found to be initiated at a restricted set of cap sites mapping 244-277 bp upstream of the coding sequence. Hence, these data suggest that the abundance of the c-myb mRNA may be regulated by a process involving selective utilization of mRNA cap sites. Sites hypersensitive to DNase I were associated with mRNA cap sites in cells that expressed c-myb.
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Registered trials
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