ArticleThe EMBO journal1987
The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.
Article in The EMBO journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 275 citations in OpenAlex.
- Article
- MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1.International journal of oral science · 2023Article
- KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1.International journal of molecular sciences · 2023Article
- Article
- Distinct projection targets define subpopulations of mouse brainstem vagal neurons that express the autism-associated MET receptor tyrosine kinase.The Journal of comparative neurology · 2017Article
- Identification of candidate genes for congenital heart defects on proximal chromosome 8p.Scientific reports · 2016Article
- Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- FERM domain containing protein 7 (FRMD7) upregulates the expression of neuronal cytoskeletal proteins and promotes neurite outgrowth in Neuro-2a cells.Molecular vision · 2012Article
- Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration.Molecular neurobiology · 2008Review
- Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.The American journal of pathology · 2004Article
- Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma.Cancer science · 2003Article
- Biotin-tagged cDNA expression libraries displayed on lambda phage: a new tool for the selection of natural protein ligands.Nucleic acids research · 2002Article
- Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease.Genome research · 2002Article
- Age-related atrophy of motor axons in mice deficient in the mid-sized neurofilament subunit.The Journal of cell biology · 1999Article
- ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells.Genes & development · 1999Article
- Characterization of the chicken transitin gene reveals a strong relationship to the nestin intermediate filament class.Journal of molecular neuroscience : MN · 1999Article
- Phototactic migration of Dictyostelium cells is linked to a new type of gelsolin-related protein.Molecular biology of the cell · 1999Article
- Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation.The Journal of cell biology · 1998Article
- Gene targeting studies begin to reveal the function of neurofilament proteins.The Journal of cell biology · 1998Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the isolation and sequence of cDNA and genomic clones for one of the two large subunits of human neurofilament, NF-M. Analysis of the sequence has allowed us to investigate the structure of the carboxy-terminal tail of this protein, and to compare it to that of the small neurofilament as well as to other intermediate filaments. The carboxy-terminal region of the protein contains a 13 amino acid proline- and serine-rich sequence repeated six times in succession. Within each repeat unit are two smaller repeats of the sequence Lys-Ser-Pro-Val. The four amino acid repeat may represent a kinase recognition site in a region of the protein that is known to be highly phosphorylated. We also note the presence of an additional heptad repeat at the extreme carboxy terminus of the protein. This region of 60 amino acids may be involved in coiled-coil interactions similar to those that facilitate the filament formation in the rod region. The human gene contains only two introns. Their positions correspond to two of the three introns found in the small neurofilament of the mouse. Thus, two of the three neurofilament genes of mammals have similar structures which are quite different from those of the other intermediate filaments. This finding suggests a common origin of the neurofilament subunits, whose evolutionary relationship to other intermediate filament genes is uncertain.
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