ReviewAnaesthesia2023
Major haemorrhage: past, present and future.
Review in Anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Machine Learning in Assessing Intraoperative Blood Loss: A Systematic Review and Meta-Analysis.International nursing review · 2026Pooled it
- Association of Anaesthetists guidelines: the use of blood components and their alternatives.Anaesthesia · 2025Guideline
- Prehospital tranexamic acid decreases early mortality in trauma patients: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial.Critical care (London, England) · 2024Trial
- The thrombelastometry parameter CTEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- A clotting time longer than 226 s in the INTEM channel of the thromboelastometer is an independent risk factor for mortality during bleeding.Die Anaesthesiologie · 2025Article
- Histone-driven hypercoagulation contributes to the lethal triad of acute trauma-induced coagulopathy.Scientific reports · 2025Article
- Article
- Association between fibrinogen levels and prognosis in critically bleeding patients: exploration of the optimal therapeutic threshold.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Applications of Hydrogels in Emergency Therapy.Gels (Basel, Switzerland) · 2025Review
- Critical trigger thresholds for hemostatic management: a narrative review of viscoelastic hemostatic assay applications.Frontiers in medicine · 2025Review
- Transfusion in trauma: empiric or guided therapy?Research and practice in thrombosis and haemostasis · 2025Article
- Biological welding: a rapid and bloodless approach to circumcision.World journal of urology · 2024Article
- Nine treatments of 1000 mL therapeutic phlebotomy in a subject with polycythemia: A case report.Physiological reports · 2024Article
- Blood Transfusion for Major Trauma in Emergency Department.Diagnostics (Basel, Switzerland) · 2024Review
- Characteristics of traumatic major haemorrhage in a tertiary trauma center.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Article
- Review
- Thromboelastometry-guided haemostatic resuscitation in severely injured patients: a propensity score-matched study.Critical care (London, England) · 2023Article
- Suboptimal Use of DOACs Post-Discharge for Geriatric Hip Fractures with Isolated Calf Deep Vein Thrombosis: Do Clinician Prescribing Preferences and Patient Compliance Alters Clinical Outcomes?Clinical interventions in aging · 2023Article
- Dynamic structures and emerging trends in the management of major trauma: A bibliometric analysis of publications between 2012 and 2021.Frontiers in public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major haemorrhage is a leading cause of morbidity and mortality worldwide. Successful treatment requires early recognition, planned responses, readily available resources (such as blood products) and rapid access to surgery or interventional radiology. Major haemorrhage is often accompanied by volume loss, haemodilution, acidaemia, hypothermia and coagulopathy (factor consumption and fibrinolysis). Management of major haemorrhage over the past decade has evolved to now deliver a 'package' of haemostatic resuscitation including: surgical or radiological control of bleeding; regular monitoring of haemostasis; advanced critical care support; and avoidance of the lethal triad of hypothermia, acidaemia and coagulopathy. Recent trial data advocate for a more personalised approach depending on the clinical scenario. Fresh frozen plasma should be given as early as possible in major trauma in a 1:1 ratio with red blood cells until the results of coagulation tests are available. Tranexamic acid is a cheap, life-saving drug and is advocated in major trauma, postpartum haemorrhage and surgery, but not in patients with gastrointestinal bleeding. Fibrinogen levels should be maintained > 2 g.l
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.