ReviewApplied microbiology and biotechnology2022
Biofilm formation and inhibition mediated by bacterial quorum sensing.
Review in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 193 citations in OpenAlex.
- Biofilm-mediated antibiotic tolerance in bacterial pathogens: Integrated molecular networks and novel therapeutic avenues.Virulence · 2026Review
- Integrated Physiological, Transcriptomic, and Gut Microbial Responses of Chinese Mitten Crab (Eriocheir sinensis) to Acute Salinity Stress.Marine biotechnology (New York, N.Y.) · 2026Article
- Biofilms on microplastics across ecological systems: Formation mechanisms, community composition, environmental impacts, and ecotoxicity.World journal of microbiology & biotechnology · 2026Review
- Engineering Smart Scaffolds for Osteomyelitis: Integrating Nanotechnology, Drug Delivery, and Tissue Regeneration-A Narrative Review.Journal of functional biomaterials · 2026Review
- Computer-Aided Identification and Molecular Interaction Analyses of Annona muricata Acetogenins Against LuxS.Biotechnology and applied biochemistry · 2026Article
- Exploring Anti-Biofilm Mechanisms of Spilanthes paniculata Essential Oil Against Oral Pathogens: An In Vitro and In Silico Study.Chemistry & biodiversity · 2026Article
- Smart Nano-Antibiotics: AI-Guided Stimuli-Responsive Nanoplatforms for Precision Antimicrobial Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- Molecular mechanisms and applications of antimicrobial secondary metabolites ofApplied and environmental microbiology · 2026Review
- Non-Cytotoxic Benzyl Triphenyl Phosphonium Bromide Is Bactericidal on MRSA and Fully Inhibits Biofilm Formation by MRSA and MRSE.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Regulatory mechanisms of quorum sensing in microbial communities and their potential applications in ruminant livestock production.Journal of advanced research · 2026Review
- Preparation, characterization, and evaluation of chitosan-thymol nanoparticles for antibacterial and antibiofilm activities against catheter-associated uropathogenic Escherichia coli.BMC biotechnology · 2026Article
- Dentin-preserving properties of cymbopogon nardus extract as a herbal endodontic irrigant againstJournal of conservative dentistry and endodontics · 2026Article
- Biomass-Based Antifouling Coatings: Mechanisms, Materials, Applications, and Emerging Sustainable Strategies.Nano-micro letters · 2026Review
- Genomic insights into probiotic functionality of Enterococcus hirae 3K isolated from Egyptian coastal sediments with special reference to exopolysaccharide production and antimicrobial activity potential.BMC microbiology · 2026Article
- Effect of Nanoparticles Type and Content on the Antimicrobial Activity of Magnetoelectric Polymer-Based Composites.Macromolecular bioscience · 2026Article
- Microbial interactions in facilitating antibiotic activity and resistance evolution.Applied and environmental microbiology · 2026Review
- Bacterial quorum-sensing systems in cell-cell communication.FEMS microbiology reviews · 2026Review
- Optimization, characterization and biological activity of siderophore produced by marine Streptomyces coelicolor.PloS one · 2026Article
- Exploring the Dynamic Culture System of biofilm-forming Bifidobacterium Adolescentis BL-8: from System establishment, Formation Mechanisms Analysis To Application in freeze-dried Probiotic Powder.Current microbiology · 2025Article
- Virulence arresting drug discovery by strategies targeting bacterial virulence: Mainly focusing on quorum-sensing interference and biofilm inhibition.Journal of pharmaceutical analysis · 2025Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
As a complex microbial aggregate, biofilm is a group behavior of bacterial ability to adapt to the environment. Bacteria produce biofilm substrates that enhance their tolerance to stress and cause microbial infections. Biofilm infection is usually closely related to virulence, pathogenicity, and even life-threatening to immunocompromised patients. Therefore, studying bacterial biofilm generation and regulatory mechanisms has become one of the most important fields. It is well known that biofilm formation involves group behavior and relies on complex regulation of quorum sensing (QS). A series of small molecule compounds such as indole, AI-2 (autoinducer-2), AHL (N-acyl-homoserine lactone), AIP (auto-inducing peptide), and DSF (diffusible signal factor) are widely available intraspecific or interspecific signaling molecules, with regulatory functions on a wide range of physiological activities of bacteria, including biofilm formation. Given that various bacteria employ QS mechanisms to regulate biofilm formation, inhibition of QS becomes a promising potential strategy for the treatment of bacterial infections. Here, we describe how bacterial intraspecific and interspecific signaling molecules regulate the mechanism of biofilm formation and dispersion. This may contribute to anti-biofilm active molecules and provide ideas or directions for studies on controlling bacterial infections by inhibiting biofilm formation through QS. KEY POINTS: • The formation and hazard of biofilm have been discussed. • The effects of quorum sensing on biofilm formation have been highlighted. • The inhibition of biofilm through quorum sensing has been discussed and highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.