ArticleJournal of intensive care2022
Benefit with preventive noninvasive ventilation in subgroups of patients at high-risk for reintubation: a post hoc analysis.
Article in Journal of intensive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- High-Flow Nasal Cannula Versus Noninvasive Ventilation for Prevention of Reintubation in High-Risk Critically Ill Patients (HIGH-FLOW OXY): An Informative Systematic Review and Meta-Analysis.Critical care explorations · 2026Pooled it
- Effect of Reintubation Within 48 Hours on Mortality in Critically Ill Patients After Planned Extubation.Respiratory care · 2024Trial
- Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial.Intensive care medicine · 2022Trial
- Temporal trends in post-extubation respiratory management and reintubation risk factors in Japan: A retrospective multicenter cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Impact of pressure support ventilation duration after a spontaneous breathing trial on reintubation rates in critically ill subjects: a retrospective study.BMC pulmonary medicine · 2025Article
- Different Ventilation Methods and Reintubation in Obese Patients.American journal of respiratory and critical care medicine · 2025Article
- The ability of diaphragmatic excursion after extubation to predict the need for resumption of ventilatory support in critically ill surgical patients.Journal of anesthesia · 2025Observational
- Assessments and exercises of cough strength in critically ill patients: a literature review.Journal of thoracic disease · 2025Review
- Best clinical model predicting extubation failure: a diagnostic accuracy post hoc analysis.Intensive care medicine · 2025Article
- Article
- Optimal Postextubation Support in Critically Ill Patients: One Size Does Not Fit All.Respiratory care · 2024Review
- High-flow nasal cannula oxygen therapy versus noninvasive ventilation for elderly chronic obstructive pulmonary disease patients after extubation: a noninferior randomized controlled trial protocol.BMC pulmonary medicine · 2024Article
- Ability of parasternal intercostal muscle thickening fraction to predict reintubation in surgical patients with sepsis.BMC anesthesiology · 2024Observational
- Peripheral perfusion index as a predictor of reintubation in critically ill surgical patients.BMC anesthesiology · 2024Observational
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-flow nasal cannula (HFNC) was shown to be non-inferior to noninvasive ventilation (NIV) for preventing reintubation in a general population of high-risk patients. However, some subgroups of high-risk patients might benefit more from NIV. We aimed to determine whether the presence of many risk factors or overweight (body mass index (BMI) ≥ 25 kg/m
methodsNot pre-specified post hoc analysis of a multicentre, randomized, controlled, non-inferiority trial comparing NFNC and NIV to prevent reintubation in patients at risk for reintubation. The original study included patients with at least 1 risk factor for reintubation.
resultsAmong 604 included in the original study, 148 had a BMI ≥ 25 kg/m
conclusionsPatients with ≥ 4 risk factors for reintubation may benefit more from preventive NIV. Based on this result, HFNC may not be the optimal preventive therapy in overweight patients. Specific trials are needed to confirm these results.
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Registered trials
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