ArticleJournal of atherosclerosis and thrombosis2023
Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study.
Article in Journal of atherosclerosis and thrombosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Enhanced Production of EPA-Derived Anti-Inflammatory Metabolites after Oral Administration of a Novel Self-Emulsifying Highly Purified EPA Ethyl Ester Formulation (MND-2119).Journal of atherosclerosis and thrombosis · 2023Trial
- Diet and Atherosclerosis Prevention: Rethinking the Significance of "The Japan Diet".Journal of atherosclerosis and thrombosis · 2026Review
- Associations of Serum Fatty Acids and the Eicosapentaenoic Acid/Arachidonic Acid Ratio with Hypertriglyceridemia in a Japanese Population: A Cross-Sectional Study.Journal of atherosclerosis and thrombosis · 2026Article
- Gender-specific associations between serum docosahexaenoic acid levels and chronic pain prevalence: a cross-sectional study.Frontiers in medicine · 2025Article
- Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis.Frontiers in immunology · 2025Article
- Article
- The Ratio of Circulating Eicosapentaenoic Acid to Arachidonic Acid Ratio in the Community-Dwelling Japanese Population.Journal of atherosclerosis and thrombosis · 2023Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimCirculating omega-3 and omega-6 polyunsaturated fatty acids may to contribute to cardiovascular health at the population level. Over a decade, we investigated changes in the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio, and in serum concentrations of the individual fatty acids, in a Japanese community.
methodsCommunity surveys took place in 2002-2003 and 2012-2013 in a rural area of Japan. The community surveys included 3,194 and 3,220 community dwellers aged ≥ 40 years who did not take EPA medication in 2002-2003 and 2012-2013, respectively. Fatty acid fractionations in serum were measured using a gas chromatography method. Changes in the serum EPA/AA ratio over time were examined using linear mixed models.
resultsOverall, the average serum EPA/AA ratio decreased over the 10 years. A decreasing trend in the serum EPA/AA ratio occurred in all age groups except participants aged ≥ 80 years, with larger decreases in the younger age groups. A similar decline in serum EPA/AA ratio occurred in participants with and those without lipid-lowering therapy. Serum EPA concentrations were slightly increased in the whole population but remained stable or even decreased in participants aged 40-69. In contrast, the average serum AA concentrations increased in all age groups.
conclusionIn a Japanese community, the serum EPA/AA ratio decreased over 10 years at the population level, especially in middle-aged participants.
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