Evidence map›Paper›PMID 36088904›Full record

ArticleNeonatology2022

Infants Born to Mothers Who Were SARS-CoV-2 Positive during Pregnancy and Admitted to Neonatal Intensive Care Unit.

Prakesh S Shah, Chloe Joynt, Stellan Håkansson, Michael Narvey, Lars Navér, Jonas Söderling, Junmin Yang, Marc Beltempo, Olof Stephansson, Deshayne B Fell and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neonatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Prakesh S ShahDepartment of Pediatrics, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
Chloe JoyntDivision of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Stellan HåkanssonDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Michael NarveyDepartment of Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada.
Lars NavérDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Jonas SöderlingClinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Junmin YangMother-Infant Research Center, Mount Sinai Hospital, Toronto, Ontario, Canada.
Marc BeltempoDepartment of Pediatrics, Montreal Children's Hospital-McGill University Health Centre, Montreal, Québec, Canada.
Olof StephanssonClinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Deshayne B FellSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Deborah MoneyDepartment of Obstetrics & Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
Joseph Y TingDivision of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Mikael NormanDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
for CNN
Karolinska University Hospital · SEMount Sinai Hospital · CAUniversity of Alberta · CAKarolinska Institutet · SEMontreal Children's Hospital · CAUmeå University · SEUniversity of British Columbia · CAUniversity of Manitoba · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOur objective was to compare neonatal outcomes and resource use of neonates born to mothers with SARS-CoV-2 positivity during pregnancy with neonates born to mothers without SARS-CoV-2 positivity.

methodsWe conducted a two-country cohort study of neonates admitted between January 1, 2020, and September 15, 2021, to tertiary neonatal intensive care unit (NICU) in Canada and Sweden. Neonates from mothers who were SARS-CoV-2 positive during pregnancy were compared with three randomly selected NICU neonates of mothers who were not test-positive, matched on gestational age, sex, and birth weight (±0.25 SD). Subgroup analyses were conducted for neonates born <33 weeks' gestation and mothers who were SARS-CoV-2 positive ≤10 days prior to birth. Primary outcome was duration of respiratory support. Secondary outcomes were in-hospital mortality, neonatal morbidity, late-onset sepsis, receipt of breast milk at discharge, and length of stay.

resultsThere were 163 exposed and 468 matched neonates in Canada, and 303 exposed and 903 matched neonates in Sweden. There was no statistically significant difference in invasive or noninvasive respiratory support durations, mortality, respiratory and other neonatal morbidities, or resource utilizations between two groups in both countries in entire cohort and in subgroup analyses. Receipt of breast milk at discharge was lower in the Canadian neonates of mothers who were SARS-CoV-2 positive ≤10 days before birth (risk ratio 0.68, 95% CI: 0.57-0.82).

conclusionMaternal SARS-CoV-2 positivity was not associated with increased durations of respiratory support, morbidities, mortality, or length of hospital stay in Canada and Sweden among neonates admitted to tertiary NICU.

Indexed as

COVID-19Pregnancy Complications, InfectiousCanadaCohort StudiesFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalIntensive Care Units, NeonatalMalePregnancyPregnancy OutcomeSARS-CoV-2COVID-19InfantMaternal positivityOutcomesPreterm

Identifiers

PMID36088904
PMCPMC9747725
OpenAlexW4295037957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.