Evidence map›Paper›PMID 36088794›Full record

ArticleVirology2022

Estimation of virus-mediated cell fusion rate of SARS-CoV-2.

Ava Amidei, Hana M Dobrovolny

Abstract read
In one paragraph

Article in Virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ava AmideiDepartment of Chemistry & Biochemistry, Texas Christian University, Fort Worth, TX, USA.
Hana M DobrovolnyDepartment of Physics & Astronomy, Texas Christian University, Fort Worth, TX, USA. Electronic address: h.dobrovolny@tcu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several viruses have the ability to form large multinucleated cells known as syncytia. Many properties of syncytia and the role they play in the evolution of a viral infection are not well understood. One basic question that has not yet been answered is how quickly syncytia form. We use a novel mathematical model of cell-cell fusion assays and apply it to experimental data from SARS-CoV-2 fusion assays to provide the first estimates of virus-mediated cell fusion rate. We find that for SARS-CoV2, the fusion rate is in the range of 6 × 10

Indexed as

COVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2Cell FusionFurinHumansRNA, ViralSpike Glycoprotein, CoronavirusVirus InternalizationAngiotensin-Converting Enzyme 2FurinRNA, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ACE2 receptorFurinFusion rateMathematical modellingSpike proteinSyncytia formationTMPRSS2

Identifiers

PMID36088794
PMCPMC9449781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.