Evidence map›Paper›PMID 36088512›Full record

ArticleDigestive diseases and sciences2023

Depression Exacerbates Dextran Sulfate Sodium-Induced Colitis via IRF5-Mediated Macrophage Polarization.

Chang Liang, Yu Tang, Xin Gao, Na Lei, Ying Luo, Pingrun Chen, Shihao Duan, Yubin Cao, Yi Yang, Yan Zhang

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In one paragraph

Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chang LiangDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Yu TangDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Xin GaoDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Na LeiDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Ying LuoDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Pingrun ChenDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Shihao DuanDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Yubin CaoDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Yi YangDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
Yan ZhangDepartment of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China. hxzyan@163.com.ORCID http://orcid.org/0000-0003-4854-1423
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPatients with inflammatory bowel disease (IBD) and concurrent depression are predisposed to severer disease activity and a worse prognosis. Macrophage polarization toward the M1 phenotype may contribute to the exacerbation of IBD with comorbid depression. Moreover, interferon regulatory factor 5 (IRF5) is involved in the pathogenesis of IBD. The aim of this study was to explore the role of IRF5 in macrophage polarization in the impact of depression upon colitis.

methodsDepressive-like behavior was induced by repeated forced swim stress. Colon length, disease activity index (DAI), colon morphology, histology, ultrastructure of epithelial barrier, lamina propria macrophage polarization, and expression of IRF5 were compared between DSS colitis rats with and without depressive-like behavior. IRF5 shRNA was constructed to affect the rat peritoneal macrophages polarization in vitro. After IRF5 shRNA lentivirus was introduced into colon by enema, the colitis severity, lamina propria macrophage polarization, and TNF-α, IL-1β, and IL-10 of colon tissues were measured.

resultsThe study found severer colonic inflammation in depressed versus non-depressed DSS-colitis rats. Depressed DSS-colitis rats exhibited smaller subepithelial macrophages size and reduced intracellular granule diversity compared with nondepressed DSS-colitis rats. Increased polarization toward the M1 phenotype, elevated expression of IRF5, and co-expression of IRF5 with CD86 were found in depressed versus nondepressed DSS-colitis rats. Lentivirus-mediated shRNA interference with IRF5 expression switched rat peritoneal macrophage polarization from the M1 to the M2 phenotype, downregulated TNF-α, IL-1β expression to a greater extent in depressed versus nondepressed colitis rats.

conclusionsIRF5-mediated macrophage polarization may likely underlie the deterioration of DSS-induced colitis caused by depression.

Indexed as

ColitisInflammatory Bowel DiseasesAnimalsColonDepressionDextran SulfateDisease Models, AnimalInterferon Regulatory FactorsMacrophagesMiceMice, Inbred C57BLRatsRNA, Small InterferingTumor Necrosis Factor-alphaDextran SulfateInterferon Regulatory FactorsIrf5 protein, mouseIRF5 protein, ratRNA, Small InterferingTumor Necrosis Factor-alphaDepressive-like behaviorDextran sulfate sodiumInflammatory bowel diseasesInterferon regulatory factor 5MacrophageStress

Identifiers

PMID36088512
OpenAlexW4295120433

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.